Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

Koji Hosomi, Mayu Saito, Jonguk Park, Haruka Murakami, Naoko Shibata, Masahiro Ando, Takahiro Nagatake, Kana Konishi, Harumi Ohno, Kumpei Tanisawa, Attayeb Mohsen, Yi-An Chen, Hitoshi Kawashima, Yayoi Natsume-Kitatani, Yoshimasa Oka, Hidenori Shimizu, Mari Furuta, Yoko Tojima, Kento Sawane, Azusa Saika, Saki Kondo, Yasunori Yonejima, Haruko Takeyama, Akira Matsutani, Kenji Mizuguchi, Motohiko Miyachi and Jun Kunisawa ()
Additional contact information
Koji Hosomi: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Mayu Saito: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Jonguk Park: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Haruka Murakami: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Naoko Shibata: Waseda University
Masahiro Ando: Waseda University
Takahiro Nagatake: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Kana Konishi: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Harumi Ohno: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Kumpei Tanisawa: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Attayeb Mohsen: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Yi-An Chen: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Hitoshi Kawashima: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Yayoi Natsume-Kitatani: National Institutes of Biomedical Innovation Health and Nutrition (NIBIOHN)
Yoshimasa Oka: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Hidenori Shimizu: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Mari Furuta: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Yoko Tojima: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Kento Sawane: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Azusa Saika: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Saki Kondo: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Yasunori Yonejima: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Haruko Takeyama: Waseda University
Akira Matsutani: Shunan City Shinnanyo Hospital
Kenji Mizuguchi: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Motohiko Miyachi: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)
Jun Kunisawa: National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract The gut microbiome is an important determinant in various diseases. Here we perform a cross-sectional study of Japanese adults and identify the Blautia genus, especially B. wexlerae, as a commensal bacterium that is inversely correlated with obesity and type 2 diabetes mellitus. Oral administration of B. wexlerae to mice induce metabolic changes and anti-inflammatory effects that decrease both high-fat diet–induced obesity and diabetes. The beneficial effects of B. wexlerae are correlated with unique amino-acid metabolism to produce S-adenosylmethionine, acetylcholine, and l-ornithine and carbohydrate metabolism resulting in the accumulation of amylopectin and production of succinate, lactate, and acetate, with simultaneous modification of the gut bacterial composition. These findings reveal unique regulatory pathways of host and microbial metabolism that may provide novel strategies in preventive and therapeutic approaches for metabolic disorders.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32015-7

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DOI: 10.1038/s41467-022-32015-7

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