Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy

Xiao Wang, Wenjing Sun, Huifang Shi, Huili Ma, Guowei Niu, Yuxin Li, Jiahuan Zhi, Xiaokang Yao, Zhicheng Song, Lei Chen, Shi Li, Guohui Yang, Zixing Zhou, Yixiao He, Shuli Qu, Min Wu, Zhu Zhao, Chengzhu Yin, Chongyang Lin, Jia Gao, Qiuying Li, Xu Zhen, Lin Li, Xiaoyuan Chen, Xiaogang Liu, Zhongfu An (), Hongmin Chen () and Wei Huang ()
Additional contact information
Xiao Wang: Nanjing Tech University
Wenjing Sun: Xiamen University
Huifang Shi: Nanjing Tech University
Huili Ma: Nanjing Tech University
Guowei Niu: Nanjing Tech University
Yuxin Li: Nanjing Tech University
Jiahuan Zhi: Nanjing Tech University
Xiaokang Yao: Nanjing Tech University
Zhicheng Song: Nanjing Tech University
Lei Chen: Xiamen University
Shi Li: Xiamen University
Guohui Yang: Nanjing Tech University
Zixing Zhou: Nanjing Tech University
Yixiao He: Nanjing Tech University
Shuli Qu: Nanjing Tech University
Min Wu: Nanjing University
Zhu Zhao: Nanjing Tech University
Chengzhu Yin: Nanjing Tech University
Chongyang Lin: Nanjing Tech University
Jia Gao: Nanjing Tech University
Qiuying Li: Nanjing Tech University
Xu Zhen: Nanjing University
Lin Li: Nanjing Tech University
Xiaoyuan Chen: National University of Singapore
Xiaogang Liu: National University of Singapore
Zhongfu An: Nanjing Tech University
Hongmin Chen: Xiamen University
Wei Huang: Nanjing Tech University

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract X-ray-induced photodynamic therapy utilizes penetrating X-rays to activate reactive oxygen species in deep tissues for cancer treatment, which combines the advantages of photodynamic therapy and radiotherapy. Conventional therapy usually requires heavy-metal-containing inorganic scintillators and organic photosensitizers to generate singlet oxygen. Here, we report a more convenient strategy for X-ray-induced photodynamic therapy based on a class of organic phosphorescence nanoscintillators, that act in a dual capacity as scintillators and photosensitizers. The resulting low dose of 0.4 Gy and negligible adverse effects demonstrate the great potential for the treatment of deep tumours. These findings provide an optional route that leverages the optical properties of purely organic scintillators for deep-tissue photodynamic therapy. Furthermore, these organic nanoscintillators offer an opportunity to expand applications in the fields of biomaterials and nanobiotechnology.

Date: 2022
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DOI: 10.1038/s41467-022-32054-0

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