Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments

Weili Wang, Huizhen Zheng, Jun Jiang, Zhi Li, Dongpeng Jiang, Xiangru Shi, Hui Wang, Jie Jiang, Qianqian Xie, Meng Gao, Jianhong Chu, Xiaoming Cai, Tian Xia and Ruibin Li ()
Additional contact information
Weili Wang: Soochow University
Huizhen Zheng: Soochow University
Jun Jiang: Soochow University
Zhi Li: Soochow University
Dongpeng Jiang: Soochow University
Xiangru Shi: Soochow University
Hui Wang: Soochow University
Jie Jiang: Soochow University
Qianqian Xie: Soochow University
Meng Gao: Soochow University
Jianhong Chu: Soochow University
Xiaoming Cai: Soochow University
Tian Xia: University of California
Ruibin Li: Soochow University

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract While hypoxia promotes carcinogenesis, tumour aggressiveness, metastasis, and resistance to oncological treatments, the impacts of hyperoxia on tumours are rarely explored because providing a long-lasting oxygen supply in vivo is a major challenge. Herein, we construct micro oxygen factories, namely, photosynthesis microcapsules (PMCs), by encapsulation of acquired cyanobacteria and upconversion nanoparticles in alginate microcapsules. This system enables a long-lasting oxygen supply through the conversion of external radiation into red-wavelength emissions for photosynthesis in cyanobacteria. PMC treatment suppresses the NF-kB pathway, HIF-1α production and cancer cell proliferation. Hyperoxic microenvironment created by an in vivo PMC implant inhibits hepatocarcinoma growth and metastasis and has synergistic effects together with anti-PD-1 in breast cancer. The engineering oxygen factories offer potential for tumour biology studies in hyperoxic microenvironments and inspire the exploration of oncological treatments.

Date: 2022
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DOI: 10.1038/s41467-022-32066-w

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