1,2-Amino oxygenation of alkenes with hydrogen evolution reaction

Shengzhang Liu, Shengchun Wang, Pengjie Wang, Zhiliang Huang (), Tao Wang () and Aiwen Lei ()
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Shengzhang Liu: Jiangxi Normal University
Shengchun Wang: The Institute for Advanced Studies (IAS) and College of Chemistry and Molecular Sciences, Wuhan University
Pengjie Wang: The Institute for Advanced Studies (IAS) and College of Chemistry and Molecular Sciences, Wuhan University
Zhiliang Huang: The Institute for Advanced Studies (IAS) and College of Chemistry and Molecular Sciences, Wuhan University
Tao Wang: Jiangxi Normal University
Aiwen Lei: Jiangxi Normal University

Nature Communications, 2022, vol. 13, issue 1, 1-7

Abstract: Abstract 1,2-Amino oxygenation of alkenes has emerged as one of the most straightforward synthetic methods to produce β-amino alcohols, which are important organic building blocks. Thus, a practical synthetic strategy for 1,2-amino oxygenation is highly desirable. Here, we reported an electro-oxidative intermolecular 1,2-amino oxygenation of alkenes with hydrogen evolution, removing the requirement of extra-oxidant. Using commercial oxygen and nitrogen sources as starting materials, this method provides a cheap, scalable, and efficient route to a set of valuable β-amino alcohol derivatives. Moreover, the merit of this protocol has been exhibited by its broad substrate scope and good application in continuous-flow reactors. Furthermore, this method can be extended to other amino-functionalization of alkenes, thereby showing the potential to inspire advances in applications of electro-induced N-centered radicals (NCRs).

Date: 2022
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DOI: 10.1038/s41467-022-32084-8

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