Levels of SARS-CoV-2 antibodies among fully vaccinated individuals with Delta or Omicron variant breakthrough infections

Nina Breinholt Stærke (), Joanne Reekie, Henrik Nielsen, Thomas Benfield, Lothar Wiese, Lene Surland Knudsen, Mette Brouw Iversen, Kasper Iversen, Kamille Fogh, Jacob Bodilsen, Maria Ruwald Juhl, Susan Olaf Lindvig, Anne Øvrehus, Lone Wulff Madsen, Vibeke Klastrup, Sidsel Dahl Andersen, Anna Karina Juhl, Signe Rode Andreasen, Sisse Rye Ostrowski, Christian Erikstrup, Thea K. Fischer, Martin Tolstrup, Lars Østergaard, Isik Somuncu Johansen, Jens Lundgren and Ole Schmeltz Søgaard
Additional contact information
Nina Breinholt Stærke: Aarhus University Hospital
Joanne Reekie: University of Copenhagen
Henrik Nielsen: Aalborg University Hospital
Thomas Benfield: Copenhagen University Hospital—Amager and Hvidovre
Lothar Wiese: Zealand University Hospital
Lene Surland Knudsen: Zealand University Hospital
Mette Brouw Iversen: Zealand University Hospital
Kasper Iversen: Herlev-Gentofte Hospital
Kamille Fogh: Herlev-Gentofte Hospital
Jacob Bodilsen: Aalborg University Hospital
Maria Ruwald Juhl: Aalborg University Hospital
Susan Olaf Lindvig: Odense University Hospital
Anne Øvrehus: Odense University Hospital
Lone Wulff Madsen: Odense University Hospital
Vibeke Klastrup: Aarhus University Hospital
Sidsel Dahl Andersen: Aarhus University Hospital
Anna Karina Juhl: Aarhus University Hospital
Signe Rode Andreasen: Aarhus University Hospital
Sisse Rye Ostrowski: University of Copenhagen
Christian Erikstrup: Aarhus University
Thea K. Fischer: University of Copenhagen
Martin Tolstrup: Aarhus University Hospital
Lars Østergaard: Aarhus University Hospital
Isik Somuncu Johansen: Odense University Hospital
Jens Lundgren: University of Copenhagen
Ole Schmeltz Søgaard: Aarhus University Hospital

Nature Communications, 2022, vol. 13, issue 1, 1-8

Abstract: Abstract SARS-CoV-2 variants of concern have continuously evolved and may erode vaccine induced immunity. In this observational cohort study, we determine the risk of breakthrough infection in a fully vaccinated cohort. SARS-CoV-2 anti-spike IgG levels were measured before first SARS-CoV-2 vaccination and at day 21–28, 90 and 180, as well as after booster vaccination. Breakthrough infections were captured through the Danish National Microbiology database. incidence rate ratio (IRR) for breakthrough infection at time-updated anti-spike IgG levels was determined using Poisson regression. Among 6076 participants, 127 and 364 breakthrough infections due to Delta and Omicron variants were observed. IRR was 0.29 (95% CI 0.15–0.56) for breakthrough infection with the Delta variant, comparing the highest and lowest quintiles of anti-spike IgG. For Omicron, no significant differences in IRR were observed. These results suggest that quantitative level of anti-spike IgG have limited impact on the risk of breakthrough infection with Omicron.

Date: 2022
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DOI: 10.1038/s41467-022-32254-8

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