Cobalt-catalyzed branched selective hydroallylation of terminal alkynes

Jieping Chen, Jiale Ying and Zhan Lu ()
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Jieping Chen: Zhejiang University
Jiale Ying: Zhejiang University
Zhan Lu: Zhejiang University

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Here, we reported a cobalt-hydride-catalyzed Markovnikov-type hydroallylation of terminal alkynes with allylic electrophile to access valuable and branched skipped dienes (1,4-dienes) with good regioselectivity. This operationally simple protocol exhibits excellent functional group tolerance and exceptional substrate scope. The reactions could be carried out in gram-scale with TON (turn over number) up to 1160, and the products could be easily derivatized. The preliminary mechanism of electrophilic allylation of α-selective cobalt alkenyl intermediate was proposed based on deuterium labeling experiment and kinetic studies.

Date: 2022
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DOI: 10.1038/s41467-022-32291-3

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