Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

Laurent Renia (), Yun Shan Goh, Angeline Rouers, Nina Bert, Wan Ni Chia, Jean-Marc Chavatte, Siew‐Wai Fong, Zi Wei Chang, Nicole Ziyi Zhuo, Matthew Zirui Tay, Yi-Hao Chan, Chee Wah Tan, Nicholas Kim‐Wah Yeo, Siti Naqiah Amrun, Yuling Huang, Joel Xu En Wong, Pei Xiang Hor, Chiew Yee Loh, Bei Wang, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Guillaume Carissimo, Samanzer Dowla, Alicia Jieling Lim, Jinyan Zhang, Joey Ming Er Lim, Cheng-I. Wang, Ying Ding, Surinder Pada, Louisa Jin Sun, Jyoti Somani, Eng Sing Lee, Desmond Luan Seng Ong, Yee‐Sin Leo, Paul A. MacAry, Raymond Tzer Pin Lin, Lin-Fa Wang, Ee Chee Ren, David C. Lye, Antonio Bertoletti, Barnaby Edward Young and Lisa F. P. Ng
Additional contact information
Laurent Renia: Technology and Research (A*STAR)
Yun Shan Goh: Technology and Research (A*STAR)
Angeline Rouers: Technology and Research (A*STAR)
Nina Bert: Duke-NUS Medical School
Wan Ni Chia: Duke-NUS Medical School
Jean-Marc Chavatte: National Public Health Laboratory
Siew‐Wai Fong: Technology and Research (A*STAR)
Zi Wei Chang: Technology and Research (A*STAR)
Nicole Ziyi Zhuo: Technology and Research (A*STAR)
Matthew Zirui Tay: Technology and Research (A*STAR)
Yi-Hao Chan: Technology and Research (A*STAR)
Chee Wah Tan: Duke-NUS Medical School
Nicholas Kim‐Wah Yeo: Technology and Research (A*STAR)
Siti Naqiah Amrun: Technology and Research (A*STAR)
Yuling Huang: Technology and Research (A*STAR)
Joel Xu En Wong: Technology and Research (A*STAR)
Pei Xiang Hor: Technology and Research (A*STAR)
Chiew Yee Loh: Technology and Research (A*STAR)
Bei Wang: Technology and Research (A*STAR)
Eve Zi Xian Ngoh: Technology and Research (A*STAR)
Siti Nazihah Mohd Salleh: Technology and Research (A*STAR)
Guillaume Carissimo: Technology and Research (A*STAR)
Samanzer Dowla: Technology and Research (A*STAR)
Alicia Jieling Lim: National Public Health Laboratory
Jinyan Zhang: Duke-NUS Medical School
Joey Ming Er Lim: Duke-NUS Medical School
Cheng-I. Wang: Technology and Research (A*STAR)
Ying Ding: National Centre for Infectious Diseases
Surinder Pada: Ng Teng Fong General Hospital
Louisa Jin Sun: Alexandra Hospital
Jyoti Somani: National University Hospital, National University Health System
Eng Sing Lee: National healthcare group polyclinic
Desmond Luan Seng Ong: National University Polyclinics, National University of Singapore
Yee‐Sin Leo: Nanyang Technological University
Paul A. MacAry: National University of Singapore
Raymond Tzer Pin Lin: National Public Health Laboratory
Lin-Fa Wang: Duke-NUS Medical School
Ee Chee Ren: Technology and Research (A*STAR)
David C. Lye: Nanyang Technological University
Antonio Bertoletti: Duke-NUS Medical School
Barnaby Edward Young: Nanyang Technological University
Lisa F. P. Ng: Technology and Research (A*STAR)

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Understanding the impact of age on vaccinations is essential for the design and delivery of vaccines against SARS-CoV-2. Here, we present findings from a comprehensive analysis of multiple compartments of the memory immune response in 312 individuals vaccinated with the BNT162b2 SARS-CoV-2 mRNA vaccine. Two vaccine doses induce high antibody and T cell responses in most individuals. However, antibody recognition of the Spike protein of the Delta and Omicron variants is less efficient than that of the ancestral Wuhan strain. Age-stratified analyses identify a group of low antibody responders where individuals ≥60 years are overrepresented. Waning of the antibody and cellular responses is observed in 30% of the vaccinees after 6 months. However, age does not influence the waning of these responses. Taken together, while individuals ≥60 years old take longer to acquire vaccine-induced immunity, they develop more sustained acquired immunity at 6 months post-vaccination. A third dose strongly boosts the low antibody responses in the older individuals against the ancestral Wuhan strain, Delta and Omicron variants.

Date: 2022
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DOI: 10.1038/s41467-022-32312-1

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