Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis

Wenjie Bao, Huayue Xing, Shiwei Cao, Xin Long, Haifeng Liu, Junwei Ma, Fan Guo, Zimu Deng () and Xiaolong Liu ()
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Wenjie Bao: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Huayue Xing: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Shiwei Cao: Shanghai Tech University
Xin Long: Chinese Academy of Sciences
Haifeng Liu: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Junwei Ma: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Fan Guo: Chinese Academy of Sciences
Zimu Deng: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Xiaolong Liu: University of Chinese Academy of Sciences, Chinese Academy of Sciences

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Disseminated intravascular coagulation (DIC) is a complication of sepsis currently lacking effective therapeutic options. Excessive inflammatory responses are emerging triggers of coagulopathy during sepsis, but the interplay between the immune system and coagulation are not fully understood. Here we utilize a murine model of intraperitoneal lipopolysaccharide stimulation and show neutrophils in the circulation mitigate the occurrence of DIC, preventing subsequent septic death. We show circulating neutrophils release extracellular vesicles containing mitochondria, which contain superoxide dismutase 2 upon exposure to lipopolysaccharide. Extracellular superoxide dismutase 2 is necessary to induce neutrophils’ antithrombotic function by preventing endothelial reactive oxygen species accumulation and alleviating endothelial dysfunction. Intervening endothelial reactive oxygen species accumulation by antioxidants significantly ameliorates disseminated intravascular coagulation improving survival in this murine model of lipopolysaccharide challenge. These findings reveal an interaction between neutrophils and vascular endothelium which critically regulate coagulation in a model of sepsis and may have potential implications for the management of disseminated intravascular coagulation.

Date: 2022
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DOI: 10.1038/s41467-022-32325-w

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