SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals

Kaori Sano, Disha Bhavsar, Gagandeep Singh, Daniel Floda, Komal Srivastava, Charles Gleason, Juan Manuel Carreño, Viviana Simon and Florian Krammer ()
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Kaori Sano: Icahn School of Medicine at Mount Sinai
Disha Bhavsar: Icahn School of Medicine at Mount Sinai
Gagandeep Singh: Icahn School of Medicine at Mount Sinai
Daniel Floda: Icahn School of Medicine at Mount Sinai
Komal Srivastava: Icahn School of Medicine at Mount Sinai
Charles Gleason: Icahn School of Medicine at Mount Sinai
Juan Manuel Carreño: Icahn School of Medicine at Mount Sinai
Viviana Simon: Icahn School of Medicine at Mount Sinai
Florian Krammer: Icahn School of Medicine at Mount Sinai

Nature Communications, 2022, vol. 13, issue 1, 1-8

Abstract: Abstract Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our results suggest mucosal SIgA responses induced by mRNA vaccination are impacted by pre-existing immunity. Indeed, vaccination induced a minimal mucosal SIgA response in individuals without pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient in patients with a history of COVID-19.

Date: 2022
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DOI: 10.1038/s41467-022-32389-8

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