Measuring anion binding at biomembrane interfaces

Xin Wu, Patrick Wang, William Lewis, Yun-Bao Jiang and Philip A. Gale ()
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Xin Wu: The University of Sydney
Patrick Wang: The University of Sydney
William Lewis: The University of Sydney
Yun-Bao Jiang: Xiamen University
Philip A. Gale: The University of Sydney

Nature Communications, 2022, vol. 13, issue 1, 1-7

Abstract: Abstract The quantification of anion binding by molecular receptors within lipid bilayers remains challenging. Here we measure anion binding in lipid bilayers by creating a fluorescent macrocycle featuring a strong sulfate affinity. We find the determinants of anion binding in lipid bilayers to be different from those expected that govern anion binding in solution. Charge-dense anions H2PO4– and Cl– that prevail in dimethyl sulfoxide fail to bind to the macrocycle in lipids. In stark contrast, ClO4– and I– that hardly bind in dimethyl sulfoxide show surprisingly significant affinities for the macrocycle in lipids. We reveal a lipid bilayer anion binding principle that depends on anion polarisability and bilayer penetration depth of complexes leading to unexpected advantages of charge-diffuse anions. These insights enhance our understanding of how biological systems select anions and guide the design of functional molecular systems operating at biomembrane interfaces.

Date: 2022
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DOI: 10.1038/s41467-022-32403-z

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