Pro-oxidant response and accelerated ferroptosis caused by synergetic Au(I) release in hypercarbon-centered gold(I) cluster prodrugs

Kui Xiao, Niyuan Zhang, Feifei Li, Dayong Hou, Xiaoyi Zhai, Wanhai Xu (), Gelin Wang (), Hao Wang () and Liang Zhao ()
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Kui Xiao: Tsinghua University
Niyuan Zhang: National Center for Nanoscience and Technology (NCNST)
Feifei Li: Tsinghua University
Dayong Hou: National Center for Nanoscience and Technology (NCNST)
Xiaoyi Zhai: Tsinghua University
Wanhai Xu: the Fourth Hospital of Harbin Medical University, Heilongjiang Key Laboratory of Scientific Research in Urology
Gelin Wang: Tsinghua University
Hao Wang: National Center for Nanoscience and Technology (NCNST)
Liang Zhao: Tsinghua University

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Medicinal applications of gold complexes have recently attracted attention due to their innovative antitumor mechanisms. In this work, two hypercoordinated carbon-centered gold clusters PAA4 and PAA5 are quantitatively synthesized by an intramolecular 6-exo-dig cyclization of polymetalated precursors. The on-bench and in vitro experimental studies demonstrate that the characteristic hypercarbon-tetragold(I) multi-center bonding in PAA4 and PAA5 not only guarantees their stability under common physiological conditions, but also facilitates a glutathione (GSH)-triggered prompt and synergetic release of active Au(I) ions in the GSH-overexpressed and acidic microenvironment of human bladder cancer EJ cells. The instantly massive release of coordination unsaturated Au(I) ions causes the efficient inhibition of thioredoxin reductases and then induces a rapid pro-oxidant response, consequently causing the occurrence of accelerated ferroptosis of EJ cells. As a result, these hypercarbon-centered gold(I) cluster prodrugs show high cytotoxicity to bladder cancer cell lines and thus exhibit a significant inhibition effect towards bladder tumors in vivo. Correlation of the synergetic domino dissociation of carbon-polymetal multi-center bonding in metal clusters with the accelerated ferroptosis of cancer cells provides a strategy for metallo-prodrugs and opens a broader prospect for the biological application of metal cluster compounds.

Date: 2022
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DOI: 10.1038/s41467-022-32474-y

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