No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial

Borja Martinez-Tellez, Guillermo Sanchez-Delgado, Francisco M. Acosta, Juan M. A. Alcantara, Francisco J. Amaro-Gahete, Wendy D. Martinez-Avila, Elisa Merchan-Ramirez, Victoria Muñoz-Hernandez, Francisco J. Osuna-Prieto, Lucas Jurado-Fasoli, Huiwen Xu, Lourdes Ortiz-Alvarez, María J. Arias-Tellez, Andrea Mendez-Gutierrez, Idoia Labayen, Francisco B. Ortega, Milena Schönke, Patrick C. N. Rensen, Concepción M. Aguilera, José M. Llamas-Elvira, Ángel Gil and Jonatan R. Ruiz ()
Additional contact information
Borja Martinez-Tellez: University of Granada
Guillermo Sanchez-Delgado: University of Granada
Francisco M. Acosta: University of Granada
Juan M. A. Alcantara: University of Granada
Francisco J. Amaro-Gahete: University of Granada
Wendy D. Martinez-Avila: University of Granada
Elisa Merchan-Ramirez: University of Granada
Victoria Muñoz-Hernandez: University of Granada
Francisco J. Osuna-Prieto: University of Granada
Lucas Jurado-Fasoli: University of Granada
Huiwen Xu: University of Granada
Lourdes Ortiz-Alvarez: University of Granada
María J. Arias-Tellez: University of Granada
Andrea Mendez-Gutierrez: University of Granada
Idoia Labayen: Public University of Navarra, Campus de Arrosadía
Francisco B. Ortega: University of Granada
Milena Schönke: Leiden University Medical Center
Patrick C. N. Rensen: Leiden University Medical Center
Concepción M. Aguilera: University of Granada
José M. Llamas-Elvira: Instituto de Investigación Biosanitaria, ibs.Granada
Ángel Gil: University of Granada
Jonatan R. Ruiz: University of Granada

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Exercise modulates both brown adipose tissue (BAT) metabolism and white adipose tissue (WAT) browning in murine models. Whether this is true in humans, however, has remained unknown. An unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to study the effects of a 24-week supervised exercise intervention, combining endurance and resistance training, on BAT volume and activity (primary outcome). The study was carried out in the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada (Spain). One hundred and forty-five young sedentary adults were assigned to either (i) a control group (no exercise, n = 54), (ii) a moderate intensity exercise group (MOD-EX, n = 48), or (iii) a vigorous intensity exercise group (VIG-EX n = 43) by unrestricted randomization. No relevant adverse events were recorded. 97 participants (34 men, 63 women) were included in the final analysis (Control; n = 35, MOD-EX; n = 31, and VIG-EX; n = 31). We observed no changes in BAT volume (Δ Control: −22.2 ± 52.6 ml; Δ MOD-EX: −15.5 ± 62.1 ml, Δ VIG-EX: −6.8 ± 66.4 ml; P = 0.771) or 18F-fluorodeoxyglucose uptake (SUVpeak Δ Control: −2.6 ± 3.1 ml; Δ MOD-EX: −1.2 ± 4.8, Δ VIG-EX: −2.2 ± 5.1; p = 0.476) in either the control or the exercise groups. Thus, we did not find any evidence of an exercise-induced change on BAT volume or activity in young sedentary adults.

Date: 2022
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DOI: 10.1038/s41467-022-32502-x

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