Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition

Leyuan Xu (), Jiankan Guo, Dennis G. Moledina and Lloyd G. Cantley ()
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Leyuan Xu: Yale University School of Medicine
Jiankan Guo: Yale University School of Medicine
Dennis G. Moledina: Yale University School of Medicine
Lloyd G. Cantley: Yale University School of Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-18

Abstract: Abstract Incomplete repair after acute kidney injury can lead to development of chronic kidney disease. To define the mechanism of this response, we compared mice subjected to identical unilateral ischemia-reperfusion kidney injury with either contralateral nephrectomy (where tubule repair predominates) or contralateral kidney intact (where tubule atrophy predominates). By day 14, the kidneys undergoing atrophy had more macrophages with higher expression of chemokines, correlating with a second wave of proinflammatory neutrophil and T cell recruitment accompanied by increased expression of tubular injury genes and a decreased proportion of differentiated tubules. Depletion of neutrophils and T cells after day 5 reduced tubular cell loss and associated kidney atrophy. In kidney biopsies from patients with acute kidney injury, T cell and neutrophil numbers negatively correlated with recovery of estimated glomerular filtration rate. Together, our findings demonstrate that macrophage persistence after injury promotes a T cell- and neutrophil-mediated proinflammatory milieu and progressive tubule damage.

Date: 2022
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DOI: 10.1038/s41467-022-32634-0

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