Control cell migration by engineering integrin ligand assembly

Xunwu Hu, Sona Rani Roy, Chengzhi Jin, Guanying Li, Qizheng Zhang, Natsuko Asano, Shunsuke Asahina, Tomoko Kajiwara, Atsushi Takahara, Bolu Feng, Kazuhiro Aoki, Chenjie Xu and Ye Zhang ()
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Xunwu Hu: Active Soft Matter Group, CAS Songshan Lake Materials Laboratory
Sona Rani Roy: Okinawa Institute of Science and Technology Graduate University
Chengzhi Jin: Okinawa Institute of Science and Technology Graduate University
Guanying Li: Okinawa Institute of Science and Technology Graduate University
Qizheng Zhang: Okinawa Institute of Science and Technology Graduate University
Natsuko Asano: SM Application Group, JEOL Ltd.
Shunsuke Asahina: SM Application Group, JEOL Ltd.
Tomoko Kajiwara: Kyushu University
Atsushi Takahara: Kyushu University
Bolu Feng: Okinawa Institute of Science and Technology Graduate University
Kazuhiro Aoki: Division of Quantitative Biology, National Institute for Basic Biology, National Institute of Natural Sciences
Chenjie Xu: City University of Hong Kong
Ye Zhang: Active Soft Matter Group, CAS Songshan Lake Materials Laboratory

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Advances in mechanistic understanding of integrin-mediated adhesion highlight the importance of precise control of ligand presentation in directing cell migration. Top-down nanopatterning limited the spatial presentation to sub-micron placing restrictions on both fundamental study and biomedical applications. To break the constraint, here we propose a bottom-up nanofabrication strategy to enhance the spatial resolution to the molecular level using simple formulation that is applicable as treatment agent. Via self-assembly and co-assembly, precise control of ligand presentation is succeeded by varying the proportions of assembling ligand and nonfunctional peptide. Assembled nanofilaments fulfill multi-functions exerting enhancement to suppression effect on cell migration with tunable amplitudes. Self-assembled nanofilaments possessing by far the highest ligand density prevent integrin/actin disassembly at cell rear, which expands the perspective of ligand-density-dependent-modulation, revealing valuable inputs to therapeutic innovations in tumor metastasis.

Date: 2022
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DOI: 10.1038/s41467-022-32686-2

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