Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina

Sarah Strauss, Maria M. Korympidou, Yanli Ran, Katrin Franke, Timm Schubert, Tom Baden, Philipp Berens, Thomas Euler () and Anna L. Vlasits ()
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Sarah Strauss: Institute for Ophthalmic Research, University of Tübingen
Maria M. Korympidou: Institute for Ophthalmic Research, University of Tübingen
Yanli Ran: Institute for Ophthalmic Research, University of Tübingen
Katrin Franke: Institute for Ophthalmic Research, University of Tübingen
Timm Schubert: Institute for Ophthalmic Research, University of Tübingen
Tom Baden: Institute for Ophthalmic Research, University of Tübingen
Philipp Berens: Institute for Ophthalmic Research, University of Tübingen
Thomas Euler: Institute for Ophthalmic Research, University of Tübingen
Anna L. Vlasits: Institute for Ophthalmic Research, University of Tübingen

Nature Communications, 2022, vol. 13, issue 1, 1-18

Abstract: Abstract Motion sensing is a critical aspect of vision. We studied the representation of motion in mouse retinal bipolar cells and found that some bipolar cells are radially direction selective, preferring the origin of small object motion trajectories. Using a glutamate sensor, we directly observed bipolar cells synaptic output and found that there are radial direction selective and non-selective bipolar cell types, the majority being selective, and that radial direction selectivity relies on properties of the center-surround receptive field. We used these bipolar cell receptive fields along with connectomics to design biophysical models of downstream cells. The models and additional experiments demonstrated that bipolar cells pass radial direction selective excitation to starburst amacrine cells, which contributes to their directional tuning. As bipolar cells provide excitation to most amacrine and ganglion cells, their radial direction selectivity may contribute to motion processing throughout the visual system.

Date: 2022
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DOI: 10.1038/s41467-022-32762-7

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