Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage

Guangyu Bao, Qiman Gao, Massimo Cau, Nabil Ali-Mohamad, Mitchell Strong, Shuaibing Jiang, Zhen Yang, Amin Valiei, Zhenwei Ma, Marco Amabili, Zu-Hua Gao, Luc Mongeau, Christian Kastrup () and Jianyu Li ()
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Guangyu Bao: McGill University
Qiman Gao: McGill University
Massimo Cau: University of British Columbia
Nabil Ali-Mohamad: University of British Columbia
Mitchell Strong: McGill University
Shuaibing Jiang: McGill University
Zhen Yang: McGill University
Amin Valiei: McGill University
Zhenwei Ma: McGill University
Marco Amabili: McGill University
Zu-Hua Gao: University of British Columbia
Luc Mongeau: McGill University
Christian Kastrup: University of British Columbia
Jianyu Li: McGill University

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Non-compressible hemorrhage is an unmet clinical challenge that accounts for high mortality in trauma. Rapid pressurized blood flows under hemorrhage impair the function and integrity of hemostatic agents and the adhesion of bioadhesive sealants. Here, we report the design and performance of bioinspired microstructured bioadhesives, formed with a macroporous tough xerogel infused with functional liquids. The xerogel can rapidly absorb interfacial fluids such as whole blood and promote blood clotting, while the infused liquids facilitate interfacial bonding, sealing, and antibacterial function. Their synergy enables the bioadhesives to form tough adhesion on ex vivo human and porcine tissues and diverse engineered surfaces without the need for compression, as well as on-demand instant removal and storage stability. We demonstrate a significantly improved hemostatic efficacy and biocompatibility in rats and pigs compared to non-structured counterparts and commercial products. This work opens new avenues for the development of bioadhesives and hemostatic sealants.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32803-1

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DOI: 10.1038/s41467-022-32803-1

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