Interrupted-time-series analysis of the immediate impact of COVID-19 mitigation measures on preterm birth in China

Yanxia Xie, Yi Mu, Peiran Chen, Zheng Liu, Yanping Wang, Qi Li, Mingrong Li, Juan Liang () and Jun Zhu ()
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Yanxia Xie: West China Second University Hospital, Sichuan University
Yi Mu: West China Second University Hospital, Sichuan University
Peiran Chen: West China Second University Hospital, Sichuan University
Zheng Liu: West China Second University Hospital, Sichuan University
Yanping Wang: West China Second University Hospital, Sichuan University
Qi Li: West China Second University Hospital, Sichuan University
Mingrong Li: West China Second University Hospital, Sichuan University
Juan Liang: West China Second University Hospital, Sichuan University
Jun Zhu: West China Second University Hospital, Sichuan University

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Preliminary evidence from China and other countries has suggested that coronavirus disease 2019 (COVID-19) mitigation measures have caused a decline in preterm births, but evidence is conflicting. Utilising a national representative data of 11,714,947 pregnant women in China, we explored the immediate changes in preterm birth rates during the COVID-19 mitigation period using an interrupted-time-series analysis. We defined the period prior to February 1, 2020 as the baseline, followed by the COVID-19 mitigation stage. In the first month of the COVID-19 mitigation, a significant absolute decrease in preterm birth rates of 0.68% (95%CI:−1.10% to −0.26%) in singleton, and of 2.80% (95%CI:−4.51% to −1.09%) in multiple births was noted. This immediate decline in Wuhan was greater than that at the national level among singleton births [−2.21% (95%CI:−4.09% to −0.34% vs. −0.68%)]. Here we report an immediate impact of COVID-19 mitigation measures on preterm birth in China.

Date: 2022
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DOI: 10.1038/s41467-022-32814-y

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