Wireless charging-mediated angiogenesis and nerve repair by adaptable microporous hydrogels from conductive building blocks

Ru-Siou Hsu, Ssu-Ju Li, Jen-Hung Fang, I-Chi Lee, Li-An Chu, Yu-Chun Lo, Yu-Jen Lu (), You-Yin Chen () and Shang-Hsiu Hu ()
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Ru-Siou Hsu: National Tsing Hua University
Ssu-Ju Li: National Yang Ming Chiao Tung University
Jen-Hung Fang: National Tsing Hua University
I-Chi Lee: National Tsing Hua University
Li-An Chu: National Tsing Hua University
Yu-Chun Lo: Taipei Medical University
Yu-Jen Lu: College of Medicine Chang Gung University
You-Yin Chen: National Yang Ming Chiao Tung University
Shang-Hsiu Hu: National Tsing Hua University

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Traumatic brain injury causes inflammation and glial scarring that impede brain tissue repair, so stimulating angiogenesis and recovery of brain function remain challenging. Here we present an adaptable conductive microporous hydrogel consisting of gold nanoyarn balls-coated injectable building blocks possessing interconnected pores to improve angiogenesis and recovery of brain function in traumatic brain injury. We show that following minimally invasive implantation, the adaptable hydrogel is able to fill defects with complex shapes and regulate the traumatic brain injury environment in a mouse model. We find that placement of this injectable hydrogel at peri-trauma regions enhances mature brain-derived neurotrophic factor by 180% and improves angiogenesis by 250% in vivo within 2 weeks after electromagnetized stimulation, and that these effects facilitate neuron survival and motor function recovery by 50%. We use blood oxygenation level-dependent functional neuroimaging to reveal the successful restoration of functional brain connectivity in the corticostriatal and corticolimbic circuits.

Date: 2022
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DOI: 10.1038/s41467-022-32912-x

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