Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology

Yixin Wu, Mingzheng Wu, Abraham Vázquez-Guardado, Joohee Kim, Xin Zhang, Raudel Avila, Jin-Tae Kim, Yujun Deng, Yongjoon Yu, Sarah Melzer, Yun Bai, Hyoseo Yoon, Lingzi Meng, Yi Zhang, Hexia Guo, Liu Hong, Evangelos E. Kanatzidis, Chad R. Haney, Emily A. Waters, Anthony R. Banks, Ziying Hu, Ferrona Lie, Leonardo P. Chamorro, Bernardo L. Sabatini, Yonggang Huang (), Yevgenia Kozorovitskiy () and John A. Rogers ()
Additional contact information
Yixin Wu: Northwestern University
Mingzheng Wu: Northwestern University
Abraham Vázquez-Guardado: Northwestern University
Joohee Kim: Northwestern University
Xin Zhang: Northwestern University
Raudel Avila: Northwestern University
Jin-Tae Kim: Northwestern University
Yujun Deng: Northwestern University
Yongjoon Yu: Neurolux Inc
Sarah Melzer: Harvard Medical School
Yun Bai: Northwestern University
Hyoseo Yoon: Northwestern University
Lingzi Meng: Northwestern University
Yi Zhang: University of Connecticut
Hexia Guo: Northwestern University
Liu Hong: University of Illinois
Evangelos E. Kanatzidis: Northwestern University
Chad R. Haney: Northwestern University
Emily A. Waters: Northwestern University
Anthony R. Banks: Northwestern University
Ziying Hu: Northwestern University
Ferrona Lie: Neurolux Inc
Leonardo P. Chamorro: University of Illinois
Bernardo L. Sabatini: Harvard Medical School
Yonggang Huang: Northwestern University
Yevgenia Kozorovitskiy: Northwestern University
John A. Rogers: Northwestern University

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract In vivo optogenetics and photopharmacology are two techniques for controlling neuronal activity that have immense potential in neuroscience research. Their applications in tether-free groups of animals have been limited in part due to tools availability. Here, we present a wireless, battery-free, programable multilateral optofluidic platform with user-selected modalities for optogenetics, pharmacology and photopharmacology. This system features mechanically compliant microfluidic and electronic interconnects, capabilities for dynamic control over the rates of drug delivery and real-time programmability, simultaneously for up to 256 separate devices in a single cage environment. Our behavioral experiments demonstrate control of motor behaviors in grouped mice through in vivo optogenetics with co-located gene delivery and controlled photolysis of caged glutamate. These optofluidic systems may expand the scope of wireless techniques to study neural processing in animal models.

Date: 2022
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DOI: 10.1038/s41467-022-32947-0

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