Bidirectional lysosome transport: a balancing act between ARL8 effectors

Agnieszka A. Kendrick () and Jenna R. Christensen ()
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Agnieszka A. Kendrick: University of California, San Diego
Jenna R. Christensen: University of California, San Diego

Nature Communications, 2022, vol. 13, issue 1, 1-3

Abstract: Most organelles move bidirectionally on microtubule tracks, yet how this opposing movement is regulated by kinesin and dynein remains unclear. Recent work found that ARL8, a known anterograde adaptor linking the lysosome to kinesin, also links lysosomes to the retrograde motor dynein, providing key insight into bidirectional organelle movement in cells.

Date: 2022
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DOI: 10.1038/s41467-022-32965-y

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