Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity

Martin J. Scurr (), George Lippiatt, Lorenzo Capitani, Kirsten Bentley, Sarah N. Lauder, Kathryn Smart, Michelle S. Somerville, Tara Rees, Richard J. Stanton, Awen Gallimore, James P. Hindley and Andrew Godkin ()
Additional contact information
Martin J. Scurr: Cardiff University
George Lippiatt: ImmunoServ Ltd.
Lorenzo Capitani: Cardiff University
Kirsten Bentley: Cardiff University
Sarah N. Lauder: Cardiff University
Kathryn Smart: Cardiff University
Michelle S. Somerville: Cardiff University
Tara Rees: Cardiff University
Richard J. Stanton: Cardiff University
Awen Gallimore: Cardiff University
James P. Hindley: ImmunoServ Ltd.
Andrew Godkin: Cardiff University

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract T cells specific for SARS-CoV-2 are thought to protect against infection and development of COVID-19, but direct evidence for this is lacking. Here, we associated whole-blood-based measurement of SARS-CoV-2-specific interferon-γ-positive T cell responses with positive COVID-19 diagnostic (PCR and/or lateral flow) test results up to 6 months post-blood sampling. Amongst 148 participants donating venous blood samples, SARS-CoV-2-specific T cell response magnitude is significantly greater in those who remain protected versus those who become infected (P

Date: 2022
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DOI: 10.1038/s41467-022-32985-8

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