In situ analysis of nanoparticle soft corona and dynamic evolution

Didar Baimanov, Jing Wang, Jun Zhang, Ke Liu, Yalin Cong, Xiaomeng Shi, Xiaohui Zhang, Yufeng Li, Xiumin Li, Rongrong Qiao, Yuliang Zhao, Yunlong Zhou (), Liming Wang () and Chunying Chen ()
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Didar Baimanov: Chinese Academy of Sciences
Jing Wang: Peking University
Jun Zhang: University of Chinese Academy of Sciences
Ke Liu: Chinese Academy of Sciences
Yalin Cong: Chinese Academy of Sciences
Xiaomeng Shi: Peking University
Xiaohui Zhang: Peking University
Yufeng Li: Chinese Academy of Sciences
Xiumin Li: Chinese Academy of Sciences
Rongrong Qiao: Chinese Academy of Sciences
Yuliang Zhao: Chinese Academy of Sciences
Yunlong Zhou: University of Chinese Academy of Sciences
Liming Wang: Chinese Academy of Sciences
Chunying Chen: Chinese Academy of Sciences

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract How soft corona, the protein corona’s outer layer, contributes to biological identity of nanomaterials is largely because capturing protein composition of the soft corona in situ remains challenging. We herein develop an in situ Fishing method that can monitor the dynamic formation of protein corona on ultra-small chiral Cu2S nanoparticles (NPs) allowing us to directly separate and identify the corona protein composition. Our method detects spatiotemporal processes in the evolution of hard and soft coronas on chiral NPs, revealing subtle differences in NP − protein interactions even within several minutes. This study highlights the importance of in situ and dynamic analysis of soft/hard corona, provides insights into the role of soft corona in mediating biological responses of NPs, and offers a universal strategy to characterize soft corona to guide the rational design of biomedical nanomaterials.

Date: 2022
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DOI: 10.1038/s41467-022-33044-y

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