An online atlas of human plasma metabolite signatures of gut microbiome composition

Koen F. Dekkers, Sergi Sayols-Baixeras, Gabriel Baldanzi, Christoph Nowak, Ulf Hammar, Diem Nguyen, Georgios Varotsis, Louise Brunkwall, Nynne Nielsen, Aron C. Eklund, Jacob Bak Holm, H. Bjørn Nielsen, Filip Ottosson, Yi-Ting Lin, Shafqat Ahmad, Lars Lind, Johan Sundström, Gunnar Engström, J. Gustav Smith, Johan Ärnlöv, Marju Orho-Melander and Tove Fall ()
Additional contact information
Koen F. Dekkers: Uppsala University
Sergi Sayols-Baixeras: Uppsala University
Gabriel Baldanzi: Uppsala University
Christoph Nowak: Karolinska Institute
Ulf Hammar: Uppsala University
Diem Nguyen: Uppsala University
Georgios Varotsis: Uppsala University
Louise Brunkwall: Lund University
Nynne Nielsen: Clinical Microbiomics A/S
Aron C. Eklund: Clinical Microbiomics A/S
Jacob Bak Holm: Clinical Microbiomics A/S
H. Bjørn Nielsen: Clinical Microbiomics A/S
Filip Ottosson: Lund University
Yi-Ting Lin: Uppsala University
Shafqat Ahmad: Uppsala University
Lars Lind: Uppsala University
Johan Sundström: Uppsala University
Gunnar Engström: Lund University
J. Gustav Smith: Sahlgrenska University Hospital
Johan Ärnlöv: Karolinska Institute
Marju Orho-Melander: Lund University
Tove Fall: Uppsala University

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these interactions is an important step towards understanding the effects of the gut microbiota on health. In this cross-sectional study, we used deep metagenomic sequencing and ultra-high-performance liquid chromatography linked to mass spectrometry for a detailed characterization of the gut microbiota and plasma metabolome, respectively, of 8583 participants invited at age 50 to 64 from the population-based Swedish CArdioPulmonary bioImage Study. Here, we find that the gut microbiota explain up to 46% of the variance of individual plasma metabolites and we present 997 associations between alpha diversity and plasma metabolites and 546,819 associations between specific gut metagenomic species and plasma metabolites in an online atlas ( https://gutsyatlas.serve.scilifelab.se/ ). We exemplify the potential of this resource by presenting novel associations between dietary factors and oral medication with the gut microbiome, and microbial species strongly associated with the uremic toxin p-cresol sulfate. This resource can be used as the basis for targeted studies of perturbation of specific metabolites and for identification of candidate plasma biomarkers of gut microbiota composition.

Date: 2022
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DOI: 10.1038/s41467-022-33050-0

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