Microgel reinforced zwitterionic hydrogel coating for blood-contacting biomedical devices

Mengmeng Yao, Zhijian Wei, Junjin Li, Zhicheng Guo, Zhuojun Yan, Xia Sun, Qingyu Yu, Xiaojun Wu, Chaojie Yu, Fanglian Yao, Shiqing Feng (), Hong Zhang () and Junjie Li ()
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Mengmeng Yao: Tianjin University
Zhijian Wei: Tianjin Medical University General Hospital
Junjin Li: Tianjin Medical University General Hospital
Zhicheng Guo: Tianjin University
Zhuojun Yan: Tianjin University
Xia Sun: Tianjin University
Qingyu Yu: Tianjin University
Xiaojun Wu: Tianjin University
Chaojie Yu: Tianjin University
Fanglian Yao: Tianjin University
Shiqing Feng: Tianjin Medical University General Hospital
Hong Zhang: Tianjin University
Junjie Li: Tianjin University

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Zwitterionic hydrogels exhibit eminent nonfouling and hemocompatibility. Several key challenges hinder their application as coating materials for blood-contacting biomedical devices, including weak mechanical strength and low adhesion to the substrate. Here, we report a poly(carboxybetaine) microgel reinforced poly(sulfobetaine) (pCBM/pSB) pure zwitterionic hydrogel with excellent mechanical robustness and anti-swelling properties. The pCBM/pSB hydrogel coating was bonded to the PVC substrate via the entanglement network between the pSB and PVC chain. Moreover, the pCBM/pSB hydrogel coating can maintain favorable stability even after 21 d PBS shearing, 0.5 h strong water flushing, 1000 underwater bends, and 100 sandpaper abrasions. Notably, the pCBM/pSB hydrogel coated PVC tubing can not only mitigate the foreign body response but also prevent thrombus formation ex vivo in rats and rabbits blood circulation without anticoagulants. This work provides new insights to guide the design of pure zwitterionic hydrogel coatings for biomedical devices.

Date: 2022
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DOI: 10.1038/s41467-022-33081-7

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