Biofeedback electrostimulation for bionic and long-lasting neural modulation

Fei Jin, Tong Li, Zhidong Wei, Ruiying Xiong, Lili Qian, Juan Ma, Tao Yuan, Qi Wu, Chengteng Lai, Xiying Ma, Fuyi Wang, Ying Zhao, Fengyu Sun, Ting Wang () and Zhang-Qi Feng ()
Additional contact information
Fei Jin: Nanjing University of Science and Technology
Tong Li: Nanjing University of Science and Technology
Zhidong Wei: Nanjing University of Science and Technology
Ruiying Xiong: Nanjing University of Science and Technology
Lili Qian: Nanjing University of Science and Technology
Juan Ma: Nanjing University of Science and Technology
Tao Yuan: Nanjing Jinling Hospital
Qi Wu: Nanjing Jinling Hospital
Chengteng Lai: Nanjing Jinling Hospital
Xiying Ma: Nanjing University of Science and Technology
Fuyi Wang: Nanjing University of Science and Technology
Ying Zhao: Nanjing University of Science and Technology
Fengyu Sun: Nanjing University of Science and Technology
Ting Wang: Southeast University
Zhang-Qi Feng: Nanjing University of Science and Technology

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Invasive electrical stimulation (iES) is prone to cause neural stimulus-inertia owing to its excessive accumulation of exogenous charges, thereby resulting in many side effects and even failure of nerve regeneration and functional recovery. Here, a wearable neural iES system is well designed and built for bionic and long-lasting neural modulation. It can automatically yield biomimetic pulsed electrical signals under the driven of respiratory motion. These electrical signals are full of unique physiological synchronization can give biofeedback to respiratory behaviors, self-adjusting with different physiological states of the living body, and thus realizing a dynamic and biological self-matched modulation of voltage-gated calcium channels on the cell membrane. Abundant cellular and animal experimental evidence confirm an effective elimination of neural stimulus-inertia by these bioelectrical signals. An unprecedented nerve regeneration and motor functional reconstruction are achieved in long-segmental peripheral nerve defects, which is equal to the gold standard of nerve repair -- autograft. The wearable neural iES system provides an advanced platform to overcome the common neural stimulus-inertia and gives a broad avenue for personalized iES therapy of nerve injury and neurodegenerative diseases.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41467-022-33089-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33089-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-33089-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().