AC amplification gain in organic electrochemical transistors for impedance-based single cell sensors

Filippo Bonafè, Francesco Decataldo, Isabella Zironi, Daniel Remondini, Tobias Cramer () and Beatrice Fraboni
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Filippo Bonafè: University of Bologna
Francesco Decataldo: University of Bologna
Isabella Zironi: University of Bologna
Daniel Remondini: University of Bologna
Tobias Cramer: University of Bologna
Beatrice Fraboni: University of Bologna

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Research on electrolyte-gated and organic electrochemical transistor (OECT) architectures is motivated by the prospect of a highly biocompatible interface capable of amplifying bioelectronic signals at the site of detection. Despite many demonstrations in these directions, a quantitative model for OECTs as impedance biosensors is still lacking. We overcome this issue by introducing a model experiment where we simulate the detection of a single cell by the impedance sensing of a dielectric microparticle. The highly reproducible experiment allows us to study the impact of transistor geometry and operation conditions on device sensitivity. With the data we rationalize a mathematical model that provides clear guidelines for the optimization of OECTs as single cell sensors, and we verify the quantitative predictions in an in-vitro experiment. In the optimized geometry, the OECT-based impedance sensor allows to record single cell adhesion and detachment transients, showing a maximum gain of 20.2±0.9 dB with respect to a single electrode-based impedance sensor.

Date: 2022
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DOI: 10.1038/s41467-022-33094-2

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