Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy

Seong Beom An, Bo-Gie Yang (), Gyeonghui Jang, Do-Yeon Kim, Jiyoung Kim, Sung-Man Oh, Nahyun Oh, Sanghee Lee, Ji-Yeong Moon, Jeong-Ah Kim, Ji-Hyun Kim, Yoo-Jeong Song, Hye-Won Hyun, Jisoo Kim, Kyungwha Lee, Dajeong Lee, Min-Jung Kwak, Byung Kwon Kim, Young-Kyu Park, Chun-Pyo Hong, Jung Hwan Kim, Hye Seong Lim, Min Sook Ryu, Hyun-Tak Jin, Seung-Woo Lee, Yoon-Seok Chang, Hae-Sim Park, Young Chul Sung () and Myoung Ho Jang ()
Additional contact information
Seong Beom An: Pohang University of Science and Technology (POSTECH)
Bo-Gie Yang: Research Institute, GI Innovation Inc., Songpa
Gyeonghui Jang: Research Institute, GI Innovation Inc., Songpa
Do-Yeon Kim: Research Institute, GI Innovation Inc., Songpa
Jiyoung Kim: Research Institute, GI Innovation Inc., Songpa
Sung-Man Oh: Research Institute, GI Innovation Inc., Songpa
Nahyun Oh: Research Institute, GI Innovation Inc., Songpa
Sanghee Lee: Research Institute, GI Innovation Inc., Songpa
Ji-Yeong Moon: Ajou University School of Medicine
Jeong-Ah Kim: Research Institute, GI Innovation Inc., Songpa
Ji-Hyun Kim: Research Institute, GI Innovation Inc., Songpa
Yoo-Jeong Song: Research Institute, GI Innovation Inc., Songpa
Hye-Won Hyun: Research Institute, GI Innovation Inc., Songpa
Jisoo Kim: Research Institute, GI Innovation Inc., Songpa
Kyungwha Lee: Research Institute, GI Innovation Inc., Songpa
Dajeong Lee: Research Institute, GI Biome Inc.
Min-Jung Kwak: Research Institute, GI Biome Inc.
Byung Kwon Kim: Research Institute, GI Biome Inc.
Young-Kyu Park: Research Institute, GI Biome Inc.
Chun-Pyo Hong: Research Institute, GI Innovation Inc., Songpa
Jung Hwan Kim: ProGen Inc.
Hye Seong Lim: ProGen Inc.
Min Sook Ryu: Ajou University School of Medicine
Hyun-Tak Jin: ProGen Inc.
Seung-Woo Lee: Pohang University of Science and Technology (POSTECH)
Yoon-Seok Chang: Seoul National University Bundang Hospital, Seoul National University College of Medicine
Hae-Sim Park: Ajou University School of Medicine
Young Chul Sung: Pohang University of Science and Technology (POSTECH)
Myoung Ho Jang: Research Institute, GI Innovation Inc., Songpa

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract IgE is central to the development of allergic diseases, and its neutralization alleviates allergic symptoms. However, most of these antibodies are based on IgG1, which is associated with an increased risk of fragment crystallizable-mediated side effects. Moreover, omalizumab, an anti-IgE antibody approved for therapeutic use, has limited benefits for patients with high IgE levels. Here, we assess a fusion protein with extracellular domain of high affinity IgE receptor, FcεRIα, linked to a IgD/IgG4 hybrid Fc domain we term IgETRAP, to reduce the risk of IgG1 Fc-mediated side effects. IgETRAP shows enhanced IgE binding affinity compared to omalizumab. We also see an enhanced therapeutic effect of IgETRAP in food allergy models when combined with Bifidobacterium longum, which results in mast cell number and free IgE levels. The combination of IgETRAP and B. longum may therefore represent a potent treatment for allergic patients with high IgE levels.

Date: 2022
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DOI: 10.1038/s41467-022-33176-1

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