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SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner

Tatiana Dandolini Saccon, Felippe Mousovich-Neto, Raissa Guimarães Ludwig, Victor Corasolla Carregari, Ana Beatriz Anjos Souza, Amanda Stephane Cruz Passos, Matheus Cavalheiro Martini, Priscilla Paschoal Barbosa, Gabriela Fabiano Souza, Stéfanie Primon Muraro, Julia Forato, Mariene Ribeiro Amorim, Rafael Elias Marques, Flavio Protasio Veras, Ester Barreto, Tiago Tomazini Gonçalves, Isadora Marques Paiva, Narayana P. B. Fazolini, Carolina Mie Kawagosi Onodera, Ronaldo Bragança Martins Junior, Paulo Henrique Cavalcanti Araújo, Sabrina Setembre Batah, Rosa Maria Mendes Viana, Danilo Machado Melo, Alexandre Todorovic Fabro, Eurico Arruda, Fernando Cunha, Thiago Mattar Cunha, Marco Antônio M. Pretti, Bradley Joseph Smith, Henrique Marques-Souza, Thiago L. Knittel, Gabriel Palermo Ruiz, Gerson S. Profeta, Tereza Cristina Minto Fontes-Cal, Mariana Boroni, Marco Aurélio Ramirez Vinolo, Alessandro S. Farias, Pedro Manoel M. Moraes-Vieira, Joyce Maria Annichino Bizzacchi, Tambet Teesalu, Felipe David Mendonça Chaim, Everton Cazzo, Elinton Adami Chaim, José Luiz Proença-Módena, Daniel Martins- de-Souza (), Mariana Kiomy Osako (), Luiz Osório Leiria () and Marcelo A. Mori ()
Additional contact information
Tatiana Dandolini Saccon: Institute of Biology, University of Campinas
Felippe Mousovich-Neto: Institute of Biology, University of Campinas
Raissa Guimarães Ludwig: Institute of Biology, University of Campinas
Victor Corasolla Carregari: Institute of Biology, University of Campinas
Ana Beatriz Anjos Souza: University of São Paulo
Amanda Stephane Cruz Passos: University of São Paulo
Matheus Cavalheiro Martini: University of Campinas
Priscilla Paschoal Barbosa: University of Campinas
Gabriela Fabiano Souza: University of Campinas
Stéfanie Primon Muraro: University of Campinas
Julia Forato: University of Campinas
Mariene Ribeiro Amorim: University of Campinas
Rafael Elias Marques: Brazilian Center for Research in Energy and Materials (CNPEM)
Flavio Protasio Veras: University of São Paulo
Ester Barreto: University of São Paulo
Tiago Tomazini Gonçalves: Center for Research in Inflammatory Diseases
Isadora Marques Paiva: University of São Paulo
Narayana P. B. Fazolini: Institute of Biology, University of Campinas
Carolina Mie Kawagosi Onodera: University of Campinas
Ronaldo Bragança Martins Junior: University of São Paulo
Paulo Henrique Cavalcanti Araújo: University of São Paulo
Sabrina Setembre Batah: University of São Paulo
Rosa Maria Mendes Viana: University of São Paulo
Danilo Machado Melo: University of São Paulo
Alexandre Todorovic Fabro: University of São Paulo
Eurico Arruda: University of São Paulo
Fernando Cunha: University of São Paulo
Thiago Mattar Cunha: University of São Paulo
Marco Antônio M. Pretti: Brazilian National Cancer Institute (INCA)
Bradley Joseph Smith: Institute of Biology, University of Campinas
Henrique Marques-Souza: Institute of Biology, University of Campinas
Thiago L. Knittel: Institute of Biology, University of Campinas
Gabriel Palermo Ruiz: Institute of Biology, University of Campinas
Gerson S. Profeta: Institute of Biology, University of Campinas
Tereza Cristina Minto Fontes-Cal: Institute of Biology, University of Campinas
Mariana Boroni: Brazilian National Cancer Institute (INCA)
Marco Aurélio Ramirez Vinolo: University of Campinas
Alessandro S. Farias: University of Campinas
Pedro Manoel M. Moraes-Vieira: University of Campinas
Joyce Maria Annichino Bizzacchi: University of Campinas
Tambet Teesalu: University of Tartu
Felipe David Mendonça Chaim: University of Campinas
Everton Cazzo: University of Campinas
Elinton Adami Chaim: University of Campinas
José Luiz Proença-Módena: University of Campinas
Daniel Martins- de-Souza: Institute of Biology, University of Campinas
Mariana Kiomy Osako: University of São Paulo
Luiz Osório Leiria: University of São Paulo
Marcelo A. Mori: Institute of Biology, University of Campinas

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue infection and disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells. However, susceptibility to infection and the cellular response depends on the anatomical origin of the cells and the viral lineage. Visceral fat cells express more ACE2 and are more susceptible to SARS-CoV-2 infection than their subcutaneous counterparts. SARS-CoV-2 infection leads to inhibition of lipolysis in subcutaneous fat cells, while in visceral fat cells, it results in higher expression of pro-inflammatory cytokines. Viral load and cellular response are attenuated when visceral fat cells are infected with the SARS-CoV-2 gamma variant. A similar degree of cell death occurs 4-days after SARS-CoV-2 infection, regardless of the cell origin or viral lineage. Hence, SARS-CoV-2 infects human fat cells, replicating and altering cell function and viability in a depot- and viral lineage-dependent fashion.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33218-8

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DOI: 10.1038/s41467-022-33218-8

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