Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care

Jinyuan Zhang, Kyunghun Kim, Ho Joong Kim, Dawn Meyer, Woohyun Park, Seul Ah Lee, Yumin Dai, Bongjoong Kim, Haesoo Moon, Jay V. Shah, Keely E. Harris, Brett Collar, Kangying Liu, Pedro Irazoqui, Hyowon Lee, Shin Ae Park (), Pete S. Kollbaum (), Bryan W. Boudouris () and Chi Hwan Lee ()
Additional contact information
Jinyuan Zhang: Purdue University
Kyunghun Kim: Purdue University
Ho Joong Kim: Purdue University
Dawn Meyer: Indiana University
Woohyun Park: Purdue University
Seul Ah Lee: Purdue University
Yumin Dai: Purdue University
Bongjoong Kim: Purdue University
Haesoo Moon: Purdue University
Jay V. Shah: Purdue University
Keely E. Harris: Purdue University
Brett Collar: Johns Hopkins University
Kangying Liu: Purdue University
Pedro Irazoqui: Johns Hopkins University
Hyowon Lee: Purdue University
Shin Ae Park: Purdue University
Pete S. Kollbaum: Purdue University
Bryan W. Boudouris: Purdue University
Chi Hwan Lee: Purdue University

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand challenge in glaucoma care. Here we introduce a class of smart soft contact lenses, enabling the continuous 24-hour monitoring of intraocular pressure, even during sleep. Uniquely, the smart soft contact lenses are built upon various commercial brands of soft contact lenses without altering their intrinsic properties such as lens power, biocompatibility, softness, transparency, wettability, oxygen transmissibility, and overnight wearability. We show that the smart soft contact lenses can seamlessly fit across different corneal curvatures and thicknesses in human eyes and therefore accurately measure absolute intraocular pressure under ambulatory conditions. We perform a comprehensive set of in vivo evaluations in rabbit, dog, and human eyes from normal to hypertension to confirm the superior measurement accuracy, within-subject repeatability, and user comfort of the smart soft contact lenses beyond current wearable ocular tonometers. We envision that the smart soft contact lenses will be effective in glaucoma care.

Date: 2022
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DOI: 10.1038/s41467-022-33254-4

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