Neural probe system for behavioral neuropharmacology by bi-directional wireless drug delivery and electrophysiology in socially interacting mice

Yousang Yoon, Hyogeun Shin, Donghak Byun, Jiwan Woo, Yakdol Cho, Nakwon Choi and Il-Joo Cho ()
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Yousang Yoon: Korea Institute of Science and Technology (KIST)
Hyogeun Shin: Korea Institute of Science and Technology (KIST)
Donghak Byun: Korea Institute of Science and Technology (KIST)
Jiwan Woo: Korea Institute of Science and Technology (KIST)
Yakdol Cho: Korea Institute of Science and Technology (KIST)
Nakwon Choi: Korea Institute of Science and Technology (KIST)
Il-Joo Cho: Korea University

Nature Communications, 2022, vol. 13, issue 1, 1-19

Abstract: Abstract Assessing the neurological and behavioral effects of drugs is important in developing pharmacological treatments, as well as understanding the mechanisms associated with neurological disorders. Herein, we present a miniaturized, wireless neural probe system with the capability of delivering drugs for the real-time investigation of the effects of the drugs on both behavioral and neural activities in socially interacting mice. We demonstrate wireless drug delivery and simultaneous monitoring of the resulting neural, behavioral changes, as well as the dose-dependent and repeatable responses to drugs. Furthermore, in pairs of mice, we use a food competition assay in which social interaction was modulated by the delivery of the drug, and the resulting changes in their neural activities are analyzed. During modulated food competition by drug injection, we observe changes in neural activity in mPFC region of a participating mouse over time. Our system may provide new opportunities for the development of studying the effects of drugs on behaviour and neural activity.

Date: 2022
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DOI: 10.1038/s41467-022-33296-8

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