Household transmission of the SARS-CoV-2 Omicron variant in Denmark

Frederik Plesner Lyngse (), Laust Hvas Mortensen, Matthew J. Denwood, Lasse Engbo Christiansen, Camilla Holten Møller, Robert Leo Skov, Katja Spiess, Anders Fomsgaard, Ria Lassaunière, Morten Rasmussen, Marc Stegger, Claus Nielsen, Raphael Niklaus Sieber, Arieh Sierra Cohen, Frederik Trier Møller, Maria Overvad, Kåre Mølbak, Tyra Grove Krause and Carsten Thure Kirkeby
Additional contact information
Frederik Plesner Lyngse: University of Copenhagen
Laust Hvas Mortensen: Statistics Denmark
Matthew J. Denwood: University of Copenhagen
Lasse Engbo Christiansen: Technical University of Denmark
Camilla Holten Møller: Statens Serum Institut
Robert Leo Skov: Statens Serum Institut
Katja Spiess: Statens Serum Institut
Anders Fomsgaard: Statens Serum Institut
Ria Lassaunière: Statens Serum Institut
Morten Rasmussen: Statens Serum Institut
Marc Stegger: Parasites and Fungi, Statens Serum Institut
Claus Nielsen: Statens Serum Institut
Raphael Niklaus Sieber: Parasites and Fungi, Statens Serum Institut
Arieh Sierra Cohen: Statens Serum Institut
Frederik Trier Møller: Statens Serum Institut
Maria Overvad: Statens Serum Institut
Kåre Mølbak: Statens Serum Institut
Tyra Grove Krause: Statens Serum Institut
Carsten Thure Kirkeby: University of Copenhagen

Nature Communications, 2022, vol. 13, issue 1, 1-7

Abstract: Abstract In late 2021, the Omicron SARS-CoV-2 variant overtook the previously dominant Delta variant, but the extent to which this transition was driven by immune evasion or a change in the inherent transmissibility is currently unclear. We estimate SARS-CoV-2 transmission within Danish households during December 2021. Among 26,675 households (8,568 with the Omicron VOC), we identified 14,140 secondary infections within a 1–7-day follow-up period. The secondary attack rate was 29% and 21% in households infected with Omicron and Delta, respectively. For Omicron, the odds of infection were 1.10 (95%-CI: 1.00-1.21) times higher for unvaccinated, 2.38 (95%-CI: 2.23-2.54) times higher for fully vaccinated and 3.20 (95%-CI: 2.67-3.83) times higher for booster-vaccinated contacts compared to Delta. We conclude that the transition from Delta to Omicron VOC was primarily driven by immune evasiveness and to a lesser extent an inherent increase in the basic transmissibility of the Omicron variant.

Date: 2022
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DOI: 10.1038/s41467-022-33328-3

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