Real-time holographic lensless micro-endoscopy through flexible fibers via fiber bundle distal holography

Noam Badt and Ori Katz ()
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Noam Badt: The Hebrew University of Jerusalem
Ori Katz: The Hebrew University of Jerusalem

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Fiber-based micro-endoscopes are a critically important tool for minimally-invasive deep-tissue imaging. However, current micro-endoscopes cannot perform three-dimensional imaging through dynamically-bent fibers without the use of bulky optical elements such as lenses and scanners at the distal end, increasing the footprint and tissue-damage. Great efforts have been invested in developing approaches that avoid distal bulky optical elements. However, the fundamental barrier of dynamic optical wavefront-distortions in propagation through flexible fibers limits current approaches to nearly-static or non-flexible fibers. Here, we present an approach that allows holographic, bend-insensitive, coherence-gated, micro-endoscopic imaging using commercially available multi-core fibers (MCFs). We achieve this by adding a partially-reflecting mirror to the distal fiber-tip, allowing to perform low-coherence full-field phase-shifting holography. We demonstrate widefield diffraction-limited reflection imaging of amplitude and phase targets through dynamically bent fibers at video-rate. Our approach holds potential for label-free investigations of dynamic samples.

Date: 2022
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DOI: 10.1038/s41467-022-33462-y

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