Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage

Stéphanie Durand, Qichao Lian, Juli Jing, Marcel Ernst, Mathilde Grelon, David Zwicker and Raphael Mercier ()
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Stéphanie Durand: Max Planck Institute for Plant Breeding Research
Qichao Lian: Max Planck Institute for Plant Breeding Research
Juli Jing: Max Planck Institute for Plant Breeding Research
Marcel Ernst: Max Planck Institute for Dynamics and Self-Organization
Mathilde Grelon: Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB)
David Zwicker: Max Planck Institute for Dynamics and Self-Organization
Raphael Mercier: Max Planck Institute for Plant Breeding Research

Nature Communications, 2022, vol. 13, issue 1, 1-13

Abstract: Abstract Meiotic crossovers are limited in number and are prevented from occurring close to each other by crossover interference. In many species, crossover number is subject to sexual dimorphism, and a lower crossover number is associated with shorter chromosome axes lengths. How this patterning is imposed remains poorly understood. Here, we show that overexpression of the Arabidopsis pro-crossover protein HEI10 increases crossovers but maintains some interference and sexual dimorphism. Disrupting the synaptonemal complex by mutating ZYP1 also leads to an increase in crossovers but, in contrast, abolishes interference and disrupts the link between chromosome axis length and crossovers. Crucially, combining HEI10 overexpression and zyp1 mutation leads to a massive and unprecedented increase in crossovers. These observations support and can be predicted by, a recently proposed model in which HEI10 diffusion along the synaptonemal complex drives a coarsening process leading to well-spaced crossover-promoting foci, providing a mechanism for crossover patterning.

Date: 2022
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DOI: 10.1038/s41467-022-33472-w

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