Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy

Bijiang Geng, Jinyan Hu, Yuan Li, Shini Feng, Dengyu Pan (), Lingyan Feng () and Longxiang Shen ()
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Bijiang Geng: Shanghai University
Jinyan Hu: Shanghai University
Yuan Li: Shanghai University
Shini Feng: Shanghai University
Dengyu Pan: Shanghai University
Lingyan Feng: Shanghai University
Longxiang Shen: Shanghai Jiao Tong University affiliated Sixth People’s Hospital

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for imaging guided sonodynamic therapy (SDT). It is challenging, however, to realize a single material that is simultaneously endowed with both NIR emitting and sonodynamic activities. Herein, we report the design of a class of NIR-emitting sonosensitizers from a NIR phosphorescent carbon dot (CD) material with a narrow bandgap (1.62 eV) and long-lived excited triplet states (11.4 μs), two of which can enhance SDT as thermodynamically and dynamically favorable factors under low-intensity ultrasound irradiation, respectively. The NIR-phosphorescent CDs are identified as bipolar quantum dots containing both p- and n-type surface functionalization regions that can drive spatial separation of e−–h+ pairs and fast transfer to reaction sites. Importantly, the cancer-specific targeting and high-level intratumor enrichment of the theranostic CDs are achieved by cancer cell membrane encapsulation for precision SDT with complete eradication of solid tumors by single injection and single irradiation. These results will open up a promising approach to engineer phosphorescent materials with long-lived triplet excited states for sonodynamic precision tumor therapy.

Date: 2022
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DOI: 10.1038/s41467-022-33474-8

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