Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance

Ankur Chakravarthy, Ian Reddin, Stephen Henderson, Cindy Dong, Nerissa Kirkwood, Maxmilan Jeyakumar, Daniela Rothschild Rodriguez, Natalia Gonzalez Martinez, Jacqueline McDermott, Xiaoping Su, Nagayasau Egawa, Christina S. Fjeldbo, Vilde Eide Skingen, Heidi Lyng, Mari Kyllesø Halle, Camilla Krakstad, Afschin Soleiman, Susanne Sprung, Matt Lechner, Peter J. I. Ellis, Mark Wass, Martin Michaelis, Heidi Fiegl, Helga Salvesen, Gareth J. Thomas, John Doorbar, Kerry Chester (), Andrew Feber () and Tim R. Fenton ()
Additional contact information
Ankur Chakravarthy: University Health Network
Ian Reddin: University of Southampton
Stephen Henderson: University College London
Cindy Dong: University of Kent
Nerissa Kirkwood: University of Kent
Maxmilan Jeyakumar: University of Kent
Daniela Rothschild Rodriguez: University of Kent
Natalia Gonzalez Martinez: University of Kent
Jacqueline McDermott: University College London
Xiaoping Su: MD Anderson Cancer Center
Nagayasau Egawa: University of Cambridge
Christina S. Fjeldbo: Oslo University Hospital
Vilde Eide Skingen: Oslo University Hospital
Heidi Lyng: Oslo University Hospital
Mari Kyllesø Halle: University of Bergen
Camilla Krakstad: University of Bergen
Afschin Soleiman: Tirol Kliniken Innsbruck
Susanne Sprung: Medical University of Innsbruck
Matt Lechner: University College London
Peter J. I. Ellis: University of Kent
Mark Wass: University of Kent
Martin Michaelis: University of Kent
Heidi Fiegl: Medical University of Innsbruck
Helga Salvesen: University of Bergen
Gareth J. Thomas: University of Southampton
John Doorbar: University of Cambridge
Kerry Chester: University College London
Andrew Feber: Royal Marsden Hospital Trust
Tim R. Fenton: University of Southampton

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer deaths in women. Here we present an integrated multi-omic analysis of 643 cervical squamous cell carcinomas (CSCC, the most common histological variant of cervical cancer), representing patient populations from the USA, Europe and Sub-Saharan Africa and identify two CSCC subtypes (C1 and C2) with differing prognosis. C1 and C2 tumours can be driven by either of the two most common HPV types in cervical cancer (16 and 18) and while HPV16 and HPV18 are overrepresented among C1 and C2 tumours respectively, the prognostic difference between groups is not due to HPV type. C2 tumours, which comprise approximately 20% of CSCCs across these cohorts, display distinct genomic alterations, including loss or mutation of the STK11 tumour suppressor gene, increased expression of several immune checkpoint genes and differences in the tumour immune microenvironment that may explain the shorter survival associated with this group. In conclusion, we identify two therapy-relevant CSCC subtypes that share the same defining characteristics across three geographically diverse cohorts.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-022-33544-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33544-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-33544-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().