Variation in the fruit development gene POINTED TIP regulates protuberance of tomato fruit tip

Jianwen Song, Lele Shang, Changxing Li, Wenqian Wang, Xin Wang, Chunli Zhang, Guo Ai, Jie Ye, Changxian Yang, Hanxia Li, Zonglie Hong, Robert M. Larkin, Zhibiao Ye and Junhong Zhang ()
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Jianwen Song: Huazhong Agricultural University
Lele Shang: Huazhong Agricultural University
Changxing Li: Huazhong Agricultural University
Wenqian Wang: Huazhong Agricultural University
Xin Wang: Huazhong Agricultural University
Chunli Zhang: Huazhong Agricultural University
Guo Ai: Huazhong Agricultural University
Jie Ye: Huazhong Agricultural University
Changxian Yang: Huazhong Agricultural University
Hanxia Li: Huazhong Agricultural University
Zonglie Hong: University of Idaho
Robert M. Larkin: Huazhong Agricultural University
Zhibiao Ye: Huazhong Agricultural University
Junhong Zhang: Huazhong Agricultural University

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract The domestication of tomato has led to striking variations in fruit morphology. Here, we show a genome-wide association study (GWAS) to understand the development of the fruit tip and describe a POINTED TIP (PT) gene that encodes a C2H2-type zinc finger transcription factor. A single nucleotide polymorphism is found to change a histidine (H) to an arginine (R) in the C2H2 domain of PT and the two alleles are referred to as PTH and PTR. Knocking out PTH leads to development of pointed tip fruit. PTH functions to suppress pointed tip formation by downregulating the transcription of FRUTFULL 2 (FUL2), which alters the auxin transport. Our evolutionary analysis and previous studies by others suggest that the PTR allele likely hitch-hiked along with other selected loci during the domestication process. This study uncovers variation in PT and molecular mechanism underlying fruit tip development in tomato.

Date: 2022
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DOI: 10.1038/s41467-022-33648-4

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