Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes

Xiaoxiao Yuan, Ruirui Wang, Bing Han, ChengJun Sun, Ruimin Chen, Haiyan Wei, Linqi Chen, Hongwei Du, Guimei Li, Yu Yang, Xiaojuan Chen, Lanwei Cui, Zhenran Xu, Junfen Fu, Jin Wu, Wei Gu, Zhihong Chen, Xin Fang, Hongxiu Yang, Zhe Su, Jing Wu, Qiuyue Li, Miaoying Zhang, Yufeng Zhou, Lei Zhang, Guang Ji () and Feihong Luo ()
Additional contact information
Xiaoxiao Yuan: Children’s Hospital of Fudan University
Ruirui Wang: Shanghai University of Traditional Chinese Medicine
Bing Han: Children’s Hospital of Fudan University
ChengJun Sun: Children’s Hospital of Fudan University
Ruimin Chen: Fuzhou Children’s Hospital of Fujian Medical University
Haiyan Wei: Children’s Hospital Affiliated to Zhengzhou University
Linqi Chen: Children’s Hospital of Soochow University
Hongwei Du: The First Hospital of Jilin University
Guimei Li: Shandong Provincial Hospital Affiliated to Shandong First Medical University
Yu Yang: The Affiliated Children’s Hospital of Nanchang University
Xiaojuan Chen: The Children’s Hospital of Shanxi Province
Lanwei Cui: The First Affiliated Hospital of Harbin Medical University
Zhenran Xu: Children’s Hospital of Fudan University
Junfen Fu: Children’s Hospital, Zhejiang University School of Medicine
Jin Wu: West China Second University Hospital, Sichuan University
Wei Gu: Children’s Hospital of Nanjing Medical University
Zhihong Chen: Affiliated Hospital of Qingdao University
Xin Fang: Fujian Medical University Union Hospital
Hongxiu Yang: Qingdao Women and Children’s Hospital
Zhe Su: Shenzhen Children’s Hospital
Jing Wu: Children’s Hospital of Fudan University
Qiuyue Li: Children’s Hospital of Fudan University
Miaoying Zhang: Children’s Hospital of Fudan University
Yufeng Zhou: Children’s Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University
Lei Zhang: Shanghai University of Traditional Chinese Medicine
Guang Ji: Shanghai University of Traditional Chinese Medicine
Feihong Luo: Children’s Hospital of Fudan University

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Gut dysbiosis has been linked to type 1 diabetes (T1D); however, microbial capacity in T1D remains unclear. Here, we integratively profiled gut microbial functional and metabolic alterations in children with new-onset T1D in independent cohorts and investigated the underlying mechanisms. In T1D, the microbiota was characterized by decreased butyrate production and bile acid metabolism and increased lipopolysaccharide biosynthesis at the species, gene, and metabolite levels. The combination of 18 bacterial species and fecal metabolites provided excellently discriminatory power for T1D. Gut microbiota from children with T1D induced elevated fasting glucose levels and declined insulin sensitivity in antibiotic-treated mice. In streptozotocin-induced T1D mice, butyrate and lipopolysaccharide exerted protective and destructive effects on islet structure and function, respectively. Lipopolysaccharide aggravated the pancreatic inflammatory response, while butyrate activated Insulin1 and Insulin2 gene expression. Our study revealed perturbed microbial functional and metabolic traits in T1D, providing potential avenues for microbiome-based prevention and intervention for T1D.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-33656-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33656-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-33656-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().