Mitochondrial network configuration influences sarcomere and myosin filament structure in striated muscles

Prasanna Katti, Alexander S. Hall, Hailey A. Parry, Peter T. Ajayi, Yuho Kim, T. Bradley Willingham, Christopher K. E. Bleck, Han Wen and Brian Glancy ()
Additional contact information
Prasanna Katti: National Institutes of Health
Alexander S. Hall: Thermo Fisher Scientific
Hailey A. Parry: National Institutes of Health
Peter T. Ajayi: National Institutes of Health
Yuho Kim: National Institutes of Health
T. Bradley Willingham: National Institutes of Health
Christopher K. E. Bleck: National Institutes of Health
Han Wen: National Institutes of Health
Brian Glancy: National Institutes of Health

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract Sustained muscle contraction occurs through interactions between actin and myosin filaments within sarcomeres and requires a constant supply of adenosine triphosphate (ATP) from nearby mitochondria. However, it remains unclear how different physical configurations between sarcomeres and mitochondria alter the energetic support for contractile function. Here, we show that sarcomere cross-sectional area (CSA) varies along its length in a cell type-dependent manner where the reduction in Z-disk CSA relative to the sarcomere center is closely coordinated with mitochondrial network configuration in flies, mice, and humans. Further, we find myosin filaments near the sarcomere periphery are curved relative to interior filaments with greater curvature for filaments near mitochondria compared to sarcoplasmic reticulum. Finally, we demonstrate variable myosin filament lattice spacing between filament ends and filament centers in a cell type-dependent manner. These data suggest both sarcomere structure and myofilament interactions are influenced by the location and orientation of mitochondria within muscle cells.

Date: 2022
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DOI: 10.1038/s41467-022-33678-y

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