Functional genomics of complex cancer genomes

Francesca Menghi () and Edison T. Liu
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Francesca Menghi: The Jackson Laboratory for Genomic Medicine
Edison T. Liu: The Jackson Laboratory for Genomic Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-4

Abstract: Cancer functional genomics is the study of how genetic, epigenetic, and transcriptional alterations affect cancer phenotypes, such as growth and therapeutic response. Here, we comment on how, taking advantage of next generation sequencing, functional genomics, often combined with systems biology approaches, has revealed novel cancer vulnerabilities beyond the original paradigm of one gene-one phenotype.

Date: 2022
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DOI: 10.1038/s41467-022-33717-8

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