Two Rac1 pools integrate the direction and coordination of collective cell migration

Sijia Zhou, Peng Li, Jiaying Liu, Juan Liao, Hao Li, Lin Chen, Zhihua Li, Qiongyu Guo, Karine Belguise, Bin Yi () and Xiaobo Wang ()
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Sijia Zhou: University of Toulouse, CNRS, UPS
Peng Li: University of Electronic Science and Technology of China
Jiaying Liu: University of Toulouse, CNRS, UPS
Juan Liao: University of Electronic Science and Technology of China
Hao Li: University of Toulouse, CNRS, UPS
Lin Chen: The Third Military Medical University (Army Medical University)
Zhihua Li: Southern University of Science and Technology
Qiongyu Guo: Southern University of Science and Technology
Karine Belguise: University of Toulouse, CNRS, UPS
Bin Yi: The Third Military Medical University (Army Medical University)
Xiaobo Wang: University of Toulouse, CNRS, UPS

Nature Communications, 2022, vol. 13, issue 1, 1-20

Abstract: Abstract Integration of collective cell direction and coordination is believed to ensure collective guidance for efficient movement. Previous studies demonstrated that chemokine receptors PVR and EGFR govern a gradient of Rac1 activity essential for collective guidance of Drosophila border cells, whose mechanistic insight is unknown. By monitoring and manipulating subcellular Rac1 activity, here we reveal two switchable Rac1 pools at border cell protrusions and supracellular cables, two important structures responsible for direction and coordination. Rac1 and Rho1 form a positive feedback loop that guides mechanical coupling at cables to achieve migration coordination. Rac1 cooperates with Cdc42 to control protrusion growth for migration direction, as well as to regulate the protrusion-cable exchange, linking direction and coordination. PVR and EGFR guide correct Rac1 activity distribution at protrusions and cables. Therefore, our studies emphasize the existence of a balance between two Rac1 pools, rather than a Rac1 activity gradient, as an integrator for the direction and coordination of collective cell migration.

Date: 2022
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DOI: 10.1038/s41467-022-33727-6

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