In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses

Yuxin Guo, Shao-Zhe Wang, Xinping Zhang, Hao-Ran Jia, Ya-Xuan Zhu, Xiaodong Zhang, Ge Gao, Yao-Wen Jiang, Chengcheng Li, Xiaokai Chen, Shun-Yu Wu, Yi Liu and Fu-Gen Wu ()
Additional contact information
Yuxin Guo: Southeast University
Shao-Zhe Wang: Southeast University
Xinping Zhang: Southeast University
Hao-Ran Jia: Southeast University
Ya-Xuan Zhu: Southeast University
Xiaodong Zhang: Southeast University
Ge Gao: Southeast University
Yao-Wen Jiang: Southeast University
Chengcheng Li: Southeast University
Xiaokai Chen: Southeast University
Shun-Yu Wu: Southeast University
Yi Liu: Southeast University
Fu-Gen Wu: Southeast University

Nature Communications, 2022, vol. 13, issue 1, 1-20

Abstract: Abstract Cancer vaccine, which can promote tumor-specific immunostimulation, is one of the most important immunotherapeutic strategies and holds tremendous potential for cancer treatment/prevention. Here, we prepare a series of nanoparticles composed of doxorubicin- and tyrosine kinase inhibitor-loaded and hyaluronic acid-coated dendritic polymers (termed HDDT nanoparticles) and find that the HDDT nanoparticles can convert various cancer cells to micrometer-sized vesicles (1.6−3.2 μm; termed HMVs) with ~100% cell-to-HMV conversion efficiency. We confirm in two tumor-bearing mouse models that the nanoparticles can restrain tumor growth, induce robust immunogenic cell death, and convert the primary tumor into an antigen depot by producing HMVs in situ to serve as personalized vaccines for cancer immunotherapy. Furthermore, the HDDT-healed mice show a strong immune memory effect and the HDDT treatment can realize long-term protection against tumor rechallenge. Collectively, the present work provides a general strategy for the preparation of tumor-associated antigen-containing vesicles and the development of personalized cancer vaccines.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-022-33831-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33831-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-33831-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().