Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern

Danique M. H. Rijswijck, Albert Bondt, Max Hoek, Karlijn Straten, Tom G. Caniels, Meliawati Poniman, Dirk Eggink, Chantal Reusken, Godelieve J. Bree, Rogier W. Sanders, Marit J. Gils and Albert J. R. Heck ()
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Danique M. H. Rijswijck: University of Utrecht
Albert Bondt: University of Utrecht
Max Hoek: University of Utrecht
Karlijn Straten: University of Amsterdam, Amsterdam Institute for Infection and Immunity
Tom G. Caniels: University of Amsterdam, Amsterdam Institute for Infection and Immunity
Meliawati Poniman: University of Amsterdam, Amsterdam Institute for Infection and Immunity
Dirk Eggink: National Institute for Public Health and the Environment, RIVM
Chantal Reusken: National Institute for Public Health and the Environment, RIVM
Godelieve J. Bree: Vrije Universiteit Amsterdam, Amsterdam Institute for Infection and Immunity
Rogier W. Sanders: University of Amsterdam, Amsterdam Institute for Infection and Immunity
Marit J. Gils: University of Amsterdam, Amsterdam Institute for Infection and Immunity
Albert J. R. Heck: University of Utrecht

Nature Communications, 2022, vol. 13, issue 1, 1-10

Abstract: Abstract Existing assays to measure antibody cross-reactivity against different SARS-CoV-2 spike (S) protein variants lack the discriminatory power to provide insights at the level of individual clones. Using a mass spectrometry-based approach we are able to monitor individual donors’ IgG1 clonal responses following a SARS-CoV-2 infection. We monitor the plasma clonal IgG1 profiles of 8 donors who had experienced an infection by either the wild type Wuhan Hu-1 virus or one of 3 VOCs (Alpha, Beta and Gamma). In these donors we chart the full plasma IgG1 repertoires as well as the IgG1 repertoires targeting the SARS-CoV-2 spike protein trimer VOC antigens. The plasma of each donor contains numerous anti-spike IgG1 antibodies, accounting for

Date: 2022
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DOI: 10.1038/s41467-022-33899-1

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