Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota

Lucas Moitinho-Silva, Frauke Degenhardt, Elke Rodriguez, Hila Emmert, Simonas Juzenas, Lena Möbus, Florian Uellendahl-Werth, Nicole Sander, Hansjörg Baurecht, Lukas Tittmann, Wolfgang Lieb, Christian Gieger, Annette Peters, David Ellinghaus, Corinna Bang, Andre Franke (), Stephan Weidinger () and Malte Christoph Rühlemann
Additional contact information
Lucas Moitinho-Silva: Kiel University
Frauke Degenhardt: Kiel University
Elke Rodriguez: University Hospital Schleswig-Holstein
Hila Emmert: University Hospital Schleswig-Holstein
Simonas Juzenas: Kiel University
Lena Möbus: University Hospital Schleswig-Holstein
Florian Uellendahl-Werth: Kiel University
Nicole Sander: University Hospital Schleswig-Holstein
Hansjörg Baurecht: University of Regensburg
Lukas Tittmann: Kiel University
Wolfgang Lieb: Kiel University
Christian Gieger: Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health
Annette Peters: Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health
David Ellinghaus: Kiel University
Corinna Bang: Kiel University
Andre Franke: Kiel University
Stephan Weidinger: University Hospital Schleswig-Holstein
Malte Christoph Rühlemann: Kiel University

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Despite the increasing knowledge about factors shaping the human microbiome, the host genetic factors that modulate the skin-microbiome interactions are still largely understudied. This contrasts with recent efforts to characterize host genes that influence the gut microbiota. Here, we investigated the effect of genetics on skin microbiota across three different skin microenvironments through meta-analyses of genome-wide association studies (GWAS) of two population-based German cohorts. We identified 23 genome-wide significant loci harboring 30 candidate genes involved in innate immune signaling, environmental sensing, cell differentiation, proliferation and fibroblast activity. However, no locus passed the strict threshold for study-wide significance (P

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33906-5

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DOI: 10.1038/s41467-022-33906-5

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