Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma

Katrin Rabold, Martijn Zoodsma, Inge Grondman, Yunus Kuijpers, Manita Bremmers, Martin Jaeger, Bowen Zhang, Willemijn Hobo, Han J. Bonenkamp, Johannes H. W. Wilt, Marcel J. R. Janssen, Lenneke A. M. Cornelissen, Ilse C. H. Engen- van Grunsven, Willem J. M. Mulder, Jan W. A. Smit, Gosse J. Adema, Mihai G. Netea, Yang Li, Cheng-Jian Xu () and Romana T. Netea-Maier ()
Additional contact information
Katrin Rabold: Radboud University Medical Center
Martijn Zoodsma: Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH)
Inge Grondman: Radboud University Medical Center
Yunus Kuijpers: Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH)
Manita Bremmers: Radboud University Medical Center
Martin Jaeger: Radboud University Medical Center
Bowen Zhang: Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH)
Willemijn Hobo: Radboud University Medical Center
Han J. Bonenkamp: Radboud University Nijmegen Medical Centre
Johannes H. W. Wilt: Radboud University Nijmegen Medical Centre
Marcel J. R. Janssen: Radboud University Nijmegen Medical Centre
Lenneke A. M. Cornelissen: Radboud University Medical Center
Ilse C. H. Engen- van Grunsven: Radboud University Nijmegen Medical Centre
Willem J. M. Mulder: Icahn School of Medicine at Mount Sinai
Jan W. A. Smit: Radboud University Medical Center
Gosse J. Adema: Radboud University Medical Center
Mihai G. Netea: Radboud University Medical Center
Yang Li: Radboud University Medical Center
Cheng-Jian Xu: Radboud University Medical Center
Romana T. Netea-Maier: Radboud University Medical Center

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Myeloid cells, crucial players in antitumoral defense, are affected by tumor-derived factors and treatment. The role of myeloid cells and their progenitors prior to tumor infiltration is poorly understood. Here we show single-cell transcriptomics and functional analyses of the myeloid cell lineage in patients with non-medullary thyroid carcinoma (TC) and multinodular goiter, before and after treatment with radioactive iodine compared to healthy controls. Integrative data analysis indicates that monocytes of TC patients have transcriptional upregulation of antigen presentation, reduced cytokine production capacity, and overproduction of reactive oxygen species. Interestingly, these cancer-related pathological changes are partially removed upon treatment. In bone marrow, TC patients tend to shift from myelopoiesis towards lymphopoiesis, reflected in transcriptional differences. Taken together, distinct transcriptional and functional changes in myeloid cells arise before their infiltration of the tumor and are already initiated in bone marrow, which suggests an active role in forming the tumor immune microenvironment.

Date: 2022
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DOI: 10.1038/s41467-022-33907-4

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