Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical

Kun-Xu Teng, Li-Ya Niu, Nan Xie and Qing-Zheng Yang ()
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Kun-Xu Teng: Beijing Normal University
Li-Ya Niu: Beijing Normal University
Nan Xie: Capital Medical University
Qing-Zheng Yang: Beijing Normal University

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Given that Type-I photosensitizers (PSs) have hypoxia tolerance, developing general approaches to prepare Type-I PSs is of great importance, but remains a challenge. Here, we report a supramolecular strategy for the preparation of Type-I photodynamic agents, which simultaneously generate strong oxidizing cationic radicals and superoxide radicals, by introducing electron acceptors to the existing Type-II PSs. As a proof-of-concept, three electron acceptors were designed and co-assembled with a classical PS to produce quadruple hydrogen-bonded supramolecular photodynamic agents. The photo-induced electron transfer from the PS to the adjacent electron acceptor occurs efficiently, leading to the generation of a strong oxidizing PS+• and an anionic radical of the acceptor, which further transfers an electron to oxygen to form O2−•. In addition, these photodynamic agents induce direct photocatalytic oxidation of NADH with a turnover frequency as high as 53.7 min−1, which offers an oxygen-independent mechanism to damage tumors.

Date: 2022
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DOI: 10.1038/s41467-022-33924-3

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