Micro-scale functional modules in the human temporal lobe

Julio I. Chapeton (), John H. Wittig, Sara K. Inati and Kareem A. Zaghloul ()
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Julio I. Chapeton: Surgical Neurology Branch, NINDS, National Institutes of Health
John H. Wittig: Surgical Neurology Branch, NINDS, National Institutes of Health
Sara K. Inati: Surgical Neurology Branch, NINDS, National Institutes of Health
Kareem A. Zaghloul: Surgical Neurology Branch, NINDS, National Institutes of Health

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract The sensory cortices of many mammals are often organized into modules in the form of cortical columns, yet whether modular organization at this spatial scale is a general property of the human neocortex is unknown. The strongest evidence for modularity arises when measures of connectivity, structure, and function converge. Here we use microelectrode recordings in humans to examine functional connectivity and neuronal spiking responses in order to assess modularity in submillimeter scale networks. We find that the human temporal lobe consists of temporally persistent spatially compact modules approximately 1.3mm in diameter. Functionally, the information coded by single neurons during an image categorization task is more similar for neurons belonging to the same module than for neurons from different modules. The geometry, connectivity, and spiking responses of these local cortical networks provide converging evidence that the human temporal lobe is organized into functional modules at the micro scale.

Date: 2022
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DOI: 10.1038/s41467-022-34018-w

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