RNA G-quadruplex structure contributes to cold adaptation in plants

Xiaofei Yang, Haopeng Yu, Susan Duncan, Yueying Zhang, Jitender Cheema, Haifeng Liu, J. Benjamin Miller, Jie Zhang, Chun Kit Kwok, Huakun Zhang () and Yiliang Ding ()
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Xiaofei Yang: Northeast Normal University
Haopeng Yu: Northeast Normal University
Susan Duncan: John Innes Centre, Norwich Research Park
Yueying Zhang: John Innes Centre, Norwich Research Park
Jitender Cheema: John Innes Centre, Norwich Research Park
Haifeng Liu: John Innes Centre, Norwich Research Park
J. Benjamin Miller: University of East Anglia, Norwich Research Park
Jie Zhang: John Innes Centre, Norwich Research Park
Chun Kit Kwok: City University of Hong Kong, Kowloon Tong
Huakun Zhang: Northeast Normal University
Yiliang Ding: John Innes Centre, Norwich Research Park

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Nucleotide composition is suggested to infer gene functionality and ecological adaptation of species to distinct environments. However, the underlying biological function of nucleotide composition dictating environmental adaptations is largely unknown. Here, we systematically analyze the nucleotide composition of transcriptomes across 1000 plants (1KP) and their corresponding habitats. Intriguingly, we find that plants growing in cold climates have guanine (G)-enriched transcriptomes, which are prone to forming RNA G-quadruplex structures. Both immunofluorescence detection and in vivo structure profiling reveal that RNA G-quadruplex formation in plants is globally enhanced in response to cold. Cold-responsive RNA G-quadruplexes strongly enhanced mRNA stability, rather than affecting translation. Disruption of individual RNA G-quadruplex promotes mRNA decay in the cold, leading to impaired plant cold response. Therefore, we propose that plants adopted RNA G-quadruplex structure as a molecular signature to facilitate their adaptation to the cold during evolution.

Date: 2022
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DOI: 10.1038/s41467-022-34040-y

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