Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure

Matthew R. Stutz, Nicholas P. Dylla, Steven D. Pearson, Paola Lecompte-Osorio, Ravi Nayak, Maryam Khalid, Emerald Adler, Jaye Boissiere, Huaiying Lin, William Leiter, Jessica Little, Amber Rose, David Moran, Michael W. Mullowney, Krysta S. Wolfe, Christopher Lehmann, Matthew Odenwald, Mark Cruz, Mihai Giurcanu, Anne S. Pohlman, Jesse B. Hall, Jean-Luc Chaubard, Anitha Sundararajan, Ashley Sidebottom, John P. Kress, Eric G. Pamer () and Bhakti K. Patel ()
Additional contact information
Matthew R. Stutz: University of Chicago Medicine
Nicholas P. Dylla: University of Chicago
Steven D. Pearson: University of Chicago Medicine
Paola Lecompte-Osorio: University of Chicago Medicine
Ravi Nayak: University of Chicago
Maryam Khalid: University of Chicago
Emerald Adler: University of Chicago
Jaye Boissiere: University of Chicago
Huaiying Lin: University of Chicago
William Leiter: University of Chicago
Jessica Little: University of Chicago
Amber Rose: University of Chicago
David Moran: University of Chicago
Michael W. Mullowney: University of Chicago
Krysta S. Wolfe: University of Chicago Medicine
Christopher Lehmann: University of Chicago Medicine
Matthew Odenwald: University of Chicago Medicine
Mark Cruz: University of Chicago Medicine
Mihai Giurcanu: University of Chicago
Anne S. Pohlman: University of Chicago Medicine
Jesse B. Hall: University of Chicago Medicine
Jean-Luc Chaubard: University of Chicago
Anitha Sundararajan: University of Chicago
Ashley Sidebottom: University of Chicago
John P. Kress: University of Chicago Medicine
Eric G. Pamer: University of Chicago
Bhakti K. Patel: University of Chicago Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Respiratory failure and mortality from COVID-19 result from virus- and inflammation-induced lung tissue damage. The intestinal microbiome and associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe COVID-19 remains unclear. We prospectively enrolled 71 patients with COVID-19 associated critical illness, collected fecal specimens within 3 days of medical intensive care unit admission, defined microbiome compositions by shotgun metagenomic sequencing, and quantified microbiota-derived metabolites (NCT #04552834). Of the 71 patients, 39 survived and 32 died. Mortality was associated with increased representation of Proteobacteria in the fecal microbiota and decreased concentrations of fecal secondary bile acids and desaminotyrosine (DAT). A microbiome metabolic profile (MMP) that accounts for fecal secondary bile acids and desaminotyrosine concentrations was independently associated with progression of respiratory failure leading to mechanical ventilation. Our findings demonstrate that fecal microbiota composition and microbiota-derived metabolite concentrations can predict the trajectory of respiratory function and death in patients with severe SARS-Cov-2 infection and suggest that the gut-lung axis plays an important role in the recovery from COVID-19.

Date: 2022
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-34260-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34260-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-34260-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().