Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration

Marketa Kaucka, Alberto Joven Araus, Marketa Tesarova, Joshua D. Currie, Johan Boström, Michaela Kavkova, Julian Petersen, Zeyu Yao, Anass Bouchnita, Andreas Hellander, Tomas Zikmund, Ahmed Elewa, Phillip T. Newton, Ji-Feng Fei, Andrei S. Chagin, Kaj Fried, Elly M. Tanaka, Jozef Kaiser, András Simon () and Igor Adameyko ()
Additional contact information
Marketa Kaucka: Max Planck Institute for Evolutionary Biology
Alberto Joven Araus: Karolinska Institute
Marketa Tesarova: Brno University of Technology
Joshua D. Currie: Wake Forest University
Johan Boström: Medical University Vienna
Michaela Kavkova: Brno University of Technology
Julian Petersen: Medical University Vienna
Zeyu Yao: Karolinska Institute
Anass Bouchnita: Uppsala University
Andreas Hellander: Uppsala University
Tomas Zikmund: Brno University of Technology
Ahmed Elewa: Karolinska Institute
Phillip T. Newton: Karolinska Institute
Ji-Feng Fei: The Research Institute of Molecular Pathology (IMP)
Andrei S. Chagin: Karolinska Institutet
Kaj Fried: Karolinska Institute
Elly M. Tanaka: The Research Institute of Molecular Pathology (IMP)
Jozef Kaiser: Brno University of Technology
András Simon: Karolinska Institute
Igor Adameyko: Medical University Vienna

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract There are major differences in duration and scale at which limb development and regeneration proceed, raising the question to what extent regeneration is a recapitulation of development. We address this by analyzing skeletal elements using a combination of micro-CT imaging, molecular profiling and clonal cell tracing. We find that, in contrast to development, regenerative skeletal growth is accomplished based entirely on cartilage expansion prior to ossification, not limiting the transversal cartilage expansion and resulting in bulkier skeletal parts. The oriented extension of salamander cartilage and bone appear similar to the development of basicranial synchondroses in mammals, as we found no evidence for cartilage stem cell niches or growth plate-like structures during neither development nor regeneration. Both regenerative and developmental ossification in salamanders start from the cortical bone and proceeds inwards, showing the diversity of schemes for the synchrony of cortical and endochondral ossification among vertebrates.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-34266-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34266-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-34266-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().