N6-methyladenosine RNA modification promotes viral genomic RNA stability and infection

Tianye Zhang, Chaonan Shi, Haichao Hu, Zhuo Zhang, Ziqiong Wang, Zhiqing Chen, Huimin Feng, Peng Liu, Jun Guo, Qisen Lu, Kaili Zhong, ZhiHui Chen, Jiaqian Liu, Jiancheng Yu, Jianping Chen (), Feng Chen () and Jian Yang ()
Additional contact information
Tianye Zhang: Ningbo University
Chaonan Shi: Henan Agricultural University
Haichao Hu: Ningbo University
Zhuo Zhang: Hunan Academy of Agricultural Sciences
Ziqiong Wang: Ningbo University
Zhiqing Chen: Ningbo University
Huimin Feng: Ningbo University
Peng Liu: Ningbo University
Jun Guo: Ningbo University
Qisen Lu: Ningbo University
Kaili Zhong: Ningbo University
ZhiHui Chen: University of Dundee, School of Life Sciences
Jiaqian Liu: Ningbo University
Jiancheng Yu: Ningbo University
Jianping Chen: Ningbo University
Feng Chen: Henan Agricultural University
Jian Yang: Ningbo University

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Molecular manipulation of susceptibility (S) genes that are antipodes to resistance (R) genes has been adopted as an alternative strategy for controlling crop diseases. Here, we show the S gene encoding Triticum aestivum m6A methyltransferase B (TaMTB) is identified by a genome-wide association study and subsequently shown to be a positive regulator for wheat yellow mosaic virus (WYMV) infection. TaMTB is localized in the nucleus, is translocated into the cytoplasmic aggregates by binding to WYMV NIb to upregulate the m6A level of WYMV RNA1 and stabilize the viral RNA, thus promoting viral infection. A natural mutant allele TaMTB-SNP176C is found to confer an enhanced susceptibility to WYMV infection through genetic variation analysis on 243 wheat varieties. Our discovery highlights this allele can be a useful target for the molecular wheat breeding in the future.

Date: 2022
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DOI: 10.1038/s41467-022-34362-x

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